Stereospecific bioactions of 5-hydroxyeicosatetraenoate. FEBS Lett 1988 Nov 21;240(1-2):163-6
Date
11/21/1988Pubmed ID
3191990DOI
10.1016/0014-5793(88)80360-0Scopus ID
2-s2.0-0024241518 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
5(S)-Hydroxyicosatetraenoate stimulates human polymorphonuclear neutrophils (PMNs) to raise their cytosolic calcium. It also potentiates the cells' degranulation responses to platelet-activating factor and diacylglycerols. We synthesized 5(R)-hydroxyicosatetraenoate and found it to be 20-100-fold weaker than the natural isomer in these assays. Thus, the arachidonic acid metabolite activates PMNs by a stereospecific possibly receptor-mediated mechanism.
Author List
Rossi AG, Thomas MJ, O'Flaherty JTAuthor
Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CalciumDiglycerides
Exocytosis
Glucuronidase
Humans
Hydroxyeicosatetraenoic Acids
Muramidase
Neutrophils
Platelet Activating Factor
Stereoisomerism
Tetradecanoylphorbol Acetate