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Stereospecific bioactions of 5-hydroxyeicosatetraenoate. FEBS Lett 1988 Nov 21;240(1-2):163-6

Date

11/21/1988

Pubmed ID

3191990

DOI

10.1016/0014-5793(88)80360-0

Scopus ID

2-s2.0-0024241518 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

5(S)-Hydroxyicosatetraenoate stimulates human polymorphonuclear neutrophils (PMNs) to raise their cytosolic calcium. It also potentiates the cells' degranulation responses to platelet-activating factor and diacylglycerols. We synthesized 5(R)-hydroxyicosatetraenoate and found it to be 20-100-fold weaker than the natural isomer in these assays. Thus, the arachidonic acid metabolite activates PMNs by a stereospecific possibly receptor-mediated mechanism.

Author List

Rossi AG, Thomas MJ, O'Flaherty JT

Author

Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Calcium
Diglycerides
Exocytosis
Glucuronidase
Humans
Hydroxyeicosatetraenoic Acids
Muramidase
Neutrophils
Platelet Activating Factor
Stereoisomerism
Tetradecanoylphorbol Acetate