Faculty Collaboration Database

Differing haemodynamic stability due to differing sympathetic response: comparison of ultrafiltration, haemodialysis and haemofiltration. Proc Eur Dial Transplant Assoc 1980;17:205-12

Date

01/01/1980

Pubmed ID

7243770

Scopus ID

2-s2.0-0019268828 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

In 12 RDT patients the volume removal related haemodynamic changes were correlated with concomitant changes in sympathetic activity during pure ultrafiltration (UF), post dilution haemofiltration (HF) and haemodialysis using either acetate (HDA) or bicarbonate (HDB) as buffer substitute. Total peripheral resistance (TPR) and plasma noradrenaline concentrations (PNA) increased during UF indicating a qualitatively adequate reaction of ESRD patients to volume removal. This physiological response is maintained during HF, resulting in intratreatment haemodynamic stability. In contrast no increase of PNA and insignificant changes of TPR were seen in HDA and HDB. As small molecule clearances were matched to those in HF, the behaviour of PNA indicates that not PNA removal but an impaired sympathetic response during HDA and HDB is responsible for the inadequate rise of TPR.

Author List

Baldamus CA, Ernst W, Fassbinder W, Koch KM

Author

Kevin M. Koch PhD Center Director, Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Blood
Female
Hemodynamics
Humans
Kidney Diseases
Male
Middle Aged
Norepinephrine
Renal Dialysis
Sympathetic Nervous System
Ultrafiltration
Vascular Resistance