Faculty Collaboration Database

Elevated plasma vasopressin (AVP) levels during resection of pheochromocytomas. Surgery 1986 Dec;100(6):1150-3

Date

12/01/1986

Pubmed ID

3787473

Scopus ID

2-s2.0-0022872536 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

During the evaluation of epidural blockade with light general anesthesia for pheochromocytoma resection, increases in plasma arginine vasopressin (AVP) concentrations were noted. We measured AVP levels in conjunction with plasma catecholamines during perioperative maneuvers in eight consecutive patients undergoing resection of pheochromocytomas. Hormonal responses (mean +/- SE) for preoperative baseline and peak values during tumor manipulation were as follows: AVP, 5 microgram/ml or picogram/ml (+/- 1.7) to a peak of 129 pg/ml (+/- 44) pg/ml; norepinephrine, 5,834 pg/ml (+/- 2,564) to 72,422 (+/- 31,433) pg/ml; epinephrine, 1,033 pg/ml (+/- 405) to 56,444 (+/- 23,542) pg/ml; and dopamine, 165 pg/ml (+/- 35) to 4,231 (+/- 1,318) pg/ml. Maximal AVP values occurred with tumor manipulation and remained elevated for 24 hours postoperatively. Neither epidural placement, induction of anesthesia, nor epidural narcotics used for postoperative pain control had any effect on AVP or catecholamine levels. These extraordinarily high concentrations of plasma AVP found during tumor manipulation may contribute to hemodynamic lability and fluid problems in patients undergoing surgery for the treatment of pheochromocytoma.

Author List

Kay J, Minkel DT, Gustafson AB, Skelton M, Cowley AW Jr, Wilson SD

Author

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adrenal Gland Neoplasms
Adult
Aged
Arginine Vasopressin
Catecholamines
Female
Hemodynamics
Humans
Intraoperative Period
Male
Middle Aged
Pheochromocytoma