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Hemodynamic and regional blood flow response to milrinone in patients with severe congestive heart failure: a dose-ranging study. Am Heart J 1987 Jul;114(1 Pt 1):97-105

Date

07/01/1987

Pubmed ID

3604878

DOI

10.1016/0002-8703(87)90313-9

Scopus ID

2-s2.0-0023239509 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

This study was undertaken to assess the hemodynamic efficacy, changes in regional blood flow, and safety of milrinone over a range of intravenous bolus injections (12.5 to 125 micrograms/kg), a continuous 18-hour infusion (0.2 to 0.7 microgram/kg/min), and following oral administration. All eighteen patients with New York Heart Association class III or IV congestive heart failure demonstrated hemodynamic improvement following intravenous bolus therapy. Dose-related increases in cardiac index occurred, ranging from a 12 +/- 6% increase following a 12.5 micrograms/kg bolus to a 37 +/- 10% increase after 75 micrograms/kg. Pulmonary wedge pressure fell 17 +/- 5% following 12.5 micrograms/kg and 28 +/- 9% following 75 micrograms/kg. Little change was apparent during the continuous infusion except for a late increase in cardiac index, but similar changes occurred in response to a single oral dose. Forearm blood flow increased significantly after 3 hours in the two higher infusion groups, but there was no consistent change in hepatic blood flow. We conclude that hemodynamic parameters and forearm blood flow are improved in patients with severe congestive heart failure following intravenous and short-term oral milrinone therapy.

Author List

Fitzpatrick PG, Cinquegrani MP, Vakiener AR, Baggs JG, Biddle TL, Liang CS, Hood WB Jr

Author

Michael P. Cinquegrani MD Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Administration, Oral
Adult
Aged
Arm
Dose-Response Relationship, Drug
Female
Heart Failure
Hemodynamics
Humans
Infusions, Intravenous
Liver Circulation
Male
Middle Aged
Milrinone
Pyridones
Regional Blood Flow