Presence of Irritable Bowel Syndrome Symptoms in Quiescent Inflammatory Bowel Disease Is Associated with High Rate of Anxiety and Depression. Dig Dis Sci 2019 Jul;64(7):1923-1928
Date
02/07/2019Pubmed ID
30725303DOI
10.1007/s10620-019-05488-8Scopus ID
2-s2.0-85061174588 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
BACKGROUND: Inflammatory bowel disease (IBD; Crohn's disease, CD and Ulcerative colitis, UC) and irritable bowel syndrome (IBS) have overlapping symptoms. Few prevalence studies of IBS in quiescent IBD have used colonoscopy with histology to confirm inactive disease. The aims were (1) to determine the percentage of IBD patients in deep remission whose persistent IBS-like symptoms (IBD/IBS+) would cause them to be classified as having active disease, based on the calculation of Harvey Bradshaw Index (HBI) or UC disease activity index (UCDAI); (2) to identify demographic and disease characteristics that are associated with IBD/IBS+.
METHODS: This was a prospective study at a single tertiary care IBD center. 96/112 patients with colonoscopy and histology confirmed quiescent disease consented and completed Rome III criteria for IBS Survey, and the hospital anxiety and depression scale (HADS). Other demographic and disease specific data were collected.
RESULTS: 36% (28/77) and 37% (7/19) of CD and UC patients, respectively, met diagnostic criteria for IBS. Significantly higher HBI/UCDAI scores (p = 0.005) and low short inflammatory bowel disease questionnaire (SIBDQ) scores (p ≤ 0.0001) were seen in IBD/IBS+ patients. 29% of patients in deep remission were mis-categorized by HBI/UCDAI as having active disease when they fulfilled Rome III criteria for IBS. Psychiatric diagnosis (OR 3.53 95% CI 1.2-10.2) and earlier onset of IBD (OR 1.056 95% CI 1.015-1.096) were associated with IBD/IBS+. Patients fulfilling IBS criteria had higher hospital anxiety and depression scale (HADS).
CONCLUSION: IBD/IBS+ affect scoring of IBD disease activity scales and become less useful in guiding treatment plans.
Author List
Perera LP, Radigan M, Guilday C, Banerjee I, Eastwood D, Babygirija R, Massey BTAuthors
Corinne Guilday PsyD Instructor in the Neurology department at Medical College of WisconsinBenson T. Massey MD Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAdult
Anxiety
Biological Products
Biopsy
Colitis, Ulcerative
Colonoscopy
Crohn Disease
Depression
Female
Humans
Immunosuppressive Agents
Irritable Bowel Syndrome
Male
Middle Aged
Prevalence
Prognosis
Prospective Studies
Remission Induction
Risk Factors
Surveys and Questionnaires
Wisconsin
Young Adult
