Faculty Collaboration Database

Oculogyric crisis: a syndrome of thought disorder and ocular deviation. Ann Neurol 1987 Jul;22(1):13-7

Date

07/01/1987

Pubmed ID

3631915

DOI

10.1002/ana.410220106

Scopus ID

2-s2.0-0023243983 (requires institutional sign-in at Scopus site)   59 Citations

Abstract

In 3 patients who suffered oculogyric crises, mental changes accompanied upward deviation of the eyes. In 1 patient, whom we studied in detail, the mental disturbance consisted of a disorder of attention in which pathological fixation of a thought occurred. During the period of upward eye deviation, all functional types of conjugate eye movements were present in the upper field of gaze, suggesting an imbalance of the vertical gaze-holding mechanism. The eyes could be driven down only by a combined blink and downward saccade. Both the thought disorder and the ocular deviation responded promptly to anticholinergic agents. We propose that the disorders of thought and eye movement in oculogyric crisis are linked by a pharmacological imbalance common to both.

Author List

Leigh RJ, Foley JM, Remler BF, Civil RH

Author

Bernd F. Remler MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Benztropine
Cognition Disorders
Diphenhydramine
Eye Movements
Female
Humans
Male
Middle Aged
Parasympatholytics
Syndrome