Anatomic and functional characteristics of the rat ileal pouch. Am J Surg 2002 Apr;183(4):464-70
Date
04/27/2002Pubmed ID
11975937DOI
10.1016/s0002-9610(02)00802-4Scopus ID
2-s2.0-0036224928 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
BACKGROUND: The definitive operation for chronic ulcerative colitis (UC) and familial adenomatous polyposis is total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Mild inflammation (pouchitis) is omnipresent in pouches and becomes severe in 50% of UC patients with IPAA. The etiology of pouchitis is likely due to combined genetic, microbial, and immunologic factors. Epithelial cell exposure to surgical trauma and/or to changes in intestinal bacterial composition may account for the inflammatory infiltrate. Progress in understanding pouchitis is restricted by the lack of suitable animal models.
METHODS: An ileal pouch-rectal anastomosis [IPRA] in rats was developed to reproduce a model of human IPAA and clinical, gross and histologic criteria were determined.
RESULTS: Many shared features with human ileal pouch were observed.
CONCLUSION: IPRA is an important in vivo model to study mechanisms of repair, defense and immunity that may contribute to pouchitis.
Author List
Chen CN, McVay LD, Batlivala ZS, Hendren SK, Swain GP, Salzman N, Williams NN, Rombeau JLAuthor
Nita H. Salzman MD, PhD Director, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anastomosis, SurgicalAnimals
Disease Models, Animal
Ileum
Lymph Nodes
Male
Mesentery
Organ Size
Peyer's Patches
Pouchitis
Proctocolectomy, Restorative
Rats
Rats, Sprague-Dawley
Rectum
Survival Rate
Time Factors
