Faculty Collaboration Database

The impact of human herpesvirus 6B reactivation on early complications following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006 Oct;12(10):1031-7

Date

10/28/2006

Pubmed ID

17067909

DOI

10.1016/j.bbmt.2006.06.001

Scopus ID

2-s2.0-33750171526 (requires institutional sign-in at Scopus site)   45 Citations

Abstract

Although human herpesvirus 6 (HHV-6) has been considered an important opportunistic and potentially fatal pathogen for allogeneic hematopoietic stem cell transplantation (HSCT), the clinical significance of HHV-6 reactivation remains controversial. In this study, we monitored HHV-6 DNAemia in 72 consecutive allogeneic HSCT recipients by real-time quantitative polymerase chain reaction. A total of 680 peripheral blood specimens were collected from the recipients before HSCT or at weekly intervals after HSCT. As the predominant variant, HHV-6B was detectable at least once in 47.2% (34/72) of HSCT recipients on the median day 21 (range, 7-84 days); HHV-6A reactivation occurred in only 1 recipient (1.4%). Detectable HHV-6B reactivation was associated with increased probability of skin rash by day 30 after HSCT (hazard ratio [HR], 3.68; 95% confidence interval [CI], 1.24-10.92; P = .019), cytomegalovirus (CMV) antigenemia (HR, 2.35; 95%CI, 1.32-4.19; P = .004), and hemorrhagic cystitis (HC) (HR, 2.59; 95%CI, 0.96-6.98; P = .061) by day 100 after HSCT. Neutrophil and platelet engraftment, mortality for 100 days after HSCT were not affected by HHV-6B reactivation. In conclusion, HHV-6 reactivation is a common event, and this study demonstrates a correlation between HHV-6B infection and CMV reactivation, early rash, and possibly increased incidence of HC after transplantation.

Author List

Wang LR, Dong LJ, Zhang MJ, Lu DP

Author

Mei-Jie Zhang PhD Professor in the Institute for Health and Equity department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Child
Cystitis
Cytomegalovirus Infections
DNA, Viral
Exanthema
Female
Graft Survival
Hematologic Neoplasms
Hemorrhage
Herpesvirus 6, Human
Hospital Mortality
Humans
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation
Postoperative Complications
Reverse Transcriptase Polymerase Chain Reaction
Roseolovirus Infections
Seizures
Transplantation Conditioning
Transplantation, Homologous
Viremia
Virus Activation