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Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity. Antimicrob Agents Chemother 2008 Dec;52(12):4463-5

Date

10/15/2008

Pubmed ID

18852279

Pubmed Central ID

PMC2592880

DOI

10.1128/AAC.00810-08

Scopus ID

2-s2.0-57049114502 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA(1-7) M(2-9) (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics.

Author List

Sato H, Feix JB

Author

Jimmy B. Feix PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Anti-Infective Agents
Antimicrobial Cationic Peptides
Gram-Negative Bacteria
Hemolysis
Humans
Lysine
Macrophages
Mice
Microbial Sensitivity Tests
Species Specificity
Staphylococcus