Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity. Antimicrob Agents Chemother 2008 Dec;52(12):4463-5
Date
10/15/2008Pubmed ID
18852279Pubmed Central ID
PMC2592880DOI
10.1128/AAC.00810-08Scopus ID
2-s2.0-57049114502 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA(1-7) M(2-9) (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics.
Author List
Sato H, Feix JBAuthor
Jimmy B. Feix PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnti-Infective Agents
Antimicrobial Cationic Peptides
Gram-Negative Bacteria
Hemolysis
Humans
Lysine
Macrophages
Mice
Microbial Sensitivity Tests
Species Specificity
Staphylococcus