Renal function and somatic growth in pediatric cadaveric renal transplantation with cyclosporine-prednisone immunosuppression. Am J Dis Child 1985 Nov;139(11):1161-7
Date
11/01/1985Pubmed ID
3904407DOI
10.1001/archpedi.1985.02140130099040Scopus ID
2-s2.0-0022229148 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
The posttransplantation courses of 28 consecutive patients (age range, 0.8 to 16 years) who received cadaveric renal allografts and combined cyclosporine-low-dose prednisone immunosuppression were analyzed. The mean follow-up time was 16.5 months (range, four to 42 months). There was one death and the actuarial one-year graft survival was 59%. At follow-up, the group mean (+/- SD) serum creatinine concentration in 14 patients with functioning grafts was nearly double the expected mean value for normal children of similar age and sex (1.13 +/- 0.38 vs 0.61 +/- 0.07 mg/dL), and the mean +/- SD glomerular filtration rate was 76.5 +/- 20.0 mL/min/1.73 sq m (range, 40 to 115.5 mL/min/1.73 sq m). Although rejection accounted for 11 (79%) of 14 graft losses, failure of immunosuppression could be implicated in only four of these patients. Among eight preadolescent patients with good renal function for one year posttransplantation, somatic growth was poor in four and suboptimal in three patients; catch-up growth occurred in one patient. In such patients, the weight-for-height index increased, reflecting the development of obesity after transplantation. We conclude that cyclosporin-low-dose prednisone offers little or no advantage in terms of cadaveric renal allograft survival or stimulation of somatic growth when compared with conventional therapy.
Author List
Ellis D, Avner ED, Rosenthal JT, Taylor RJ, Young LW, Palumbi MA, Hakala TRAuthor
Ellis D. Avner MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAge Determination by Skeleton
Cadaver
Child
Child, Preschool
Creatinine
Cyclosporins
Drug Combinations
Female
Follow-Up Studies
Graft Rejection
Graft Survival
Growth
Hirsutism
Histocompatibility Testing
Humans
Hypertension
Kidney
Kidney Transplantation
Male
Postoperative Complications
Prednisone
Tissue Donors
