Faculty Collaboration Database

Effects of behavioral intervention on substance use among people living with HIV: the Healthy Living Project randomized controlled study. Addiction 2008 Jul;103(7):1206-14

Date

05/23/2008

Pubmed ID

18494840

Pubmed Central ID

PMC2665995

DOI

10.1111/j.1360-0443.2008.02222.x

Scopus ID

2-s2.0-45149132488 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

AIM: Reductions in substance use were examined in response to an intensive intervention with people living with human immunodeficiency virus (HIV) (PLH).

DESIGN, SETTING AND PARTICIPANTS: A randomized controlled trial was conducted with 936 PLH who had recently engaged in unprotected sexual risk acts recruited from four US cities: Milwaukee, San Francisco, New York and Los Angeles. Substance use was assessed as the number of days of use of 19 substances recently (over the last 90 days), evaluated at 5-month intervals over 25 months.

INTERVENTION: A 15-session case management intervention was delivered to PLH in the intervention condition; the control condition received usual care.

MEASUREMENTS: An intention-to-treat analysis was conducted examining reductions on multiple indices of recent substance use calculated as the number of days of use.

FINDINGS: Reductions in recent substance use were significantly greater for intervention PLH compared to control PLH: alcohol and/or marijuana use, any substance use, hard drug use and a weighted index adjusting for seriousness of the drug. While the intervention-related reductions in substance use were larger among women than men, men also reduced their use. Compared to controls, gay and heterosexual men in the intervention reduced significantly their use of alcohol and marijuana, any substance, stimulants and the drug severity-weighted frequency of use index. Gay men also reduced their hard drug use significantly in the intervention compared to the control condition.

CONCLUSIONS: A case management intervention model, delivered individually, is likely to result in significant and sustained reductions in substance use among PLH.

Author List

Wong FL, Rotheram-Borus MJ, Lightfoot M, Pequegnat W, Comulada WS, Cumberland W, Weinhardt LS, Remien RH, Chesney M, Johnson M, Healthy Living Trial Group

Authors

Jeffrey A. Kelly PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Lance S. Weinhardt MS,PhD Associate Dean for Research and Professor of Community and Behavioral Health Promotion in the Joseph. J. Zilber School of Public Health department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Behavior Therapy
Female
HIV Infections
Humans
Male
Middle Aged
Patient Compliance
Risk Reduction Behavior
Sexual Behavior
Substance Abuse, Intravenous
Treatment Outcome
United States