Improved neurologic function after long-term correction of vitamin E deficiency in children with chronic cholestasis. N Engl J Med 1985 Dec 19;313(25):1580-6
Date
12/19/1985Pubmed ID
4069170DOI
10.1056/NEJM198512193132505Scopus ID
2-s2.0-0022413170 (requires institutional sign-in at Scopus site) 126 CitationsAbstract
We studied the effect of long-term correction of vitamin E deficiency on neurologic function in 14 children with chronic cholestasis. Vitamin E repletion was achieved in all, either by large oral doses (up to 120 IU per kilogram of body weight per day) or by intramuscular administration of dl-alpha-tocopherol (0.8 to 2.0 IU per kilogram per day). With early institution of therapy, neurologic function remained normal in two asymptomatic children below the age of three years after 15 and 18 months of therapy. Neurologic function became normal in three symptomatic children below age three after 18 to 32 months of therapy. Restitution of neurologic function was more limited in nine symptomatic children 5 to 17 1/2 years old after 18 to 48 months of therapy. We conclude that vitamin E repletion therapy should be initiated at an early age in children with chronic cholestasis complicated by vitamin E deficiency, to prevent irreversible neurologic injury.
Author List
Sokol RJ, Guggenheim MA, Iannaccone ST, Barkhaus PE, Miller C, Silverman A, Balistreri WF, Heubi JEAuthor
Paul E. Barkhaus MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAtaxia
Child
Child, Preschool
Cholestasis
Chronic Disease
Female
Humans
Infant
Male
Nervous System Diseases
Neurologic Examination
Peripheral Nerves
Vitamin E
Vitamin E Deficiency
