Faculty Collaboration Database

Long-term treatment of plastic bronchitis with aerosolized tissue plasminogen activator in a Fontan patient. Pediatr Crit Care Med 2005 Jan;6(1):76-8

Date

01/08/2005

Pubmed ID

15636664

DOI

10.1097/01.PCC.0000149320.06424.1D

Scopus ID

2-s2.0-21744458795 (requires institutional sign-in at Scopus site)   47 Citations

Abstract

OBJECTIVE: To report the successful treatment of plastic bronchitis with aerosolized tissue plasminogen activator.

DESIGN: Case report.

PATIENTS: A 4-yr-old boy with congenital heart disease, who developed plastic bronchitis 33 months after a Fontan operation

INTERVENTIONS: Long-term treatment with aerosolized tissue plasminogen activator.

MEASUREMENTS AND MAIN RESULTS: We describe the case of a boy who developed recurrent episodes of life-threatening airway obstruction secondary to plastic bronchitis. Following the failure of multiple therapeutic interventions, his condition improved significantly with aerosolized tissue plasminogen activator. Several attempts to wean him off this treatment resulted in clinical deterioration. He has remained on long-term aerosolized tissue plasminogen activator.

CONCLUSION: Treatment of plastic bronchitis with aerosolized tissue plasminogen activator may benefit patients in whom other therapies have failed.

Author List

Wakeham MK, Van Bergen AH, Torero LE, Akhter J

Author

Martin K. Wakeham MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Administration, Inhalation
Airway Obstruction
Bronchiolitis Obliterans
Child, Preschool
Fontan Procedure
Heart Defects, Congenital
Humans
Male
Plasminogen Activators
Recurrence
Tissue Plasminogen Activator
Treatment Outcome