X marks the spot: does it matter that O-GlcNAc transferase is an X-linked gene? Biochem Biophys Res Commun 2014 Oct 17;453(2):201-7
Date
06/25/2014Pubmed ID
24960196Pubmed Central ID
PMC4253714DOI
10.1016/j.bbrc.2014.06.068Scopus ID
2-s2.0-84906216635 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
O-GlcNAcylation has emerged as a critical post-translational modification important for a wide array of cellular processes. This modification has been identified on a large pool of intracellular proteins that have wide-ranging roles, including transcriptional regulation, cell cycle progression, and signaling, among others. Interestingly, in mammals the single gene encoding O-GlcNAc Transferase (OGT) is located on the X-chromosome near the Xist locus suggesting that tight dosage regulation is necessary for normal development. Herein, we highlight the importance of OGT dosage and consider how its genomic location can contribute to a gender-specific increased risk for a number of diseases.
Author List
Olivier-Van Stichelen S, Abramowitz LK, Hanover JAAuthor
Stephanie Olivier-Van Stichelen PhD Assistant Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcetylglucosamineAnimals
Dosage Compensation, Genetic
Embryonic Development
Female
Genes, X-Linked
Genomic Imprinting
Glycosylation
Humans
Male
Mice
Models, Biological
N-Acetylglucosaminyltransferases
Pregnancy
Protein Processing, Post-Translational
X Chromosome Inactivation
