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Neutrophil chemokine production in the skin following scald injury. Burns 1999 Aug;25(5):403-10

Date

08/10/1999

Pubmed ID

10439148

DOI

10.1016/s0305-4179(99)00014-5

Abstract

The present study was conducted to determine whether local production of neutrophil chemoattractant cytokines preceded the influx of neutrophils following dermal scald injury. To accomplish this, dermal tissue was examined for inflammatory infiltrate and the level of KC, a murine homolog of human interleukin-8, at various time points after scald injury. The studies reveal that there was a largely neutrophilic infiltrate at 1 day post-injury which persisted for 4 days. Dermal KC levels increased significantly at 4 h, returned to baseline at 8 h and were elevated again from 1 to 3 days post-burn (P < 0.01). At 3 days post-burn, KC was elevated 15-fold above the level in sham treated mice (P < 0.01). These observations demonstrate that the influx of neutrophils into the skin follows the expression of KC in the skin. This suggests that it should be possible to alter neutrophil accumulation at the wound site by manipulating the local chemokine signal.

Author List

Faunce DE, Llanas JN, Patel PJ, Gregory MS, Duffner LA, Kovacs EJ

Author

Parag J. Patel MD, MS, FSIR Professor in the Radiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Burns
Chemokine CXCL1
Chemokines
Chemokines, CXC
Cytokines
Inflammation Mediators
Interleukin-8
Male
Mice
Neutrophils
Peroxidase
Skin
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00