Faculty Collaboration Database

Comparison of the QTDT analysis for IgE in the CSGA data set. Genet Epidemiol 2001;21 Suppl 1:S312-6

Date

01/17/2002

Pubmed ID

11793690

DOI

10.1002/gepi.2001.21.s1.s312

Scopus ID

2-s2.0-0034793129 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log10IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis.

Author List

Page GP, Wilcox MA, Occhiuto J, Adak S, Neuberg D, Bajorunaite R, George V

Author

Ruta Brazauskas PhD Associate Professor in the Data Science Institute department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Asthma
Child
Female
Genetic Markers
Genetics, Population
Humans
Immunoglobulin E
Linkage Disequilibrium
Lod Score
Male
Quantitative Trait, Heritable
United States