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Halothane anesthesia attenuates cardiopulmonary baroreflex control of peripheral resistance in humans. Anesthesiology 1985 Dec;63(6):668-74

Date

12/01/1985

Pubmed ID

4061921

DOI

10.1097/00000542-198512000-00018

Scopus ID

2-s2.0-0022359118 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

The effects of halothane anesthesia on cardiopulmonary (low pressure) baroreflex control of peripheral resistance were studied in 10 ASA class I young men. Graded (-5, -7.5, -10, -12.5 mmHg) lower body negative pressure (LBNP) was used to produce progressive decreases in thoracic blood volume and central venous pressure. These stimuli activate reflexes from cardiopulmonary baroreceptors. Volunteers were studied while awake and during 1 MAC (0.75%) and 1.25 MAC (0.93%) halothane anesthesia. Hetastarch (6%) in 0.9% normal saline was infused into patients before baseline recordings were initiated. Blood pressure, stroke volume, cardiac output, and systemic and forearm vascular resistance decreased and forearm blood flow increased during halothane anesthesia. In awake subjects, LBNP did not alter heart rate or blood pressure, but stroke volume and cardiac output decreased. Blood pressure was maintained by cardiopulmonary baroreflex-mediated increases in peripheral resistance. In anesthetized subjects, decreases in stroke volume and cardiac output during LBNP were similar to awake responses, however, hypotension occurred because reflex resistance increases were markedly attenuated. The authors conclude that halothane anesthesia blunts cardiopulmonary baroreflex resistance responses provoked by mild decreases in thoracic blood volume in humans.

Author List

Ebert TJ, Kotrly KJ, Vucins EJ, Pattison CZ, Kampine JP

Author

Thomas J. Ebert MD, PhD Adjunct Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Anesthesia, Inhalation
Blood Volume
Central Venous Pressure
Halothane
Heart
Hemodynamics
Humans
Lower Body Negative Pressure
Lung
Male
Pressoreceptors
Reflex
Vascular Resistance