Mesh term Thyroid Nuclear Factor 1
Browse to parent terms:Homeodomain Proteins
Nuclear Proteins
Transcription Factors
Description
A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.Search for this term in our Faculty Database
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