Mesh term Centromere Protein A
Browse to parent terms:Autoantigens
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Poly-ADP-Ribose Binding Proteins
Description
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.Search for this term in our Faculty Database
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