Mesh term Cytochrome P-450 Enzyme System
Browse to parent terms:Cytochromes
Mixed Function Oxygenases
Description
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Browse to child terms:
Aryl Hydrocarbon Hydroxylases
Camphor 5-Monooxygenase
Cytochrome P450 Family 1
Cytochrome P450 Family 11
Cytochrome P450 Family 12
Cytochrome P450 Family 17
Cytochrome P450 Family 19
Cytochrome P450 Family 2
Cytochrome P450 Family 21
Cytochrome P450 Family 24
Cytochrome P450 Family 26
Cytochrome P450 Family 27
Cytochrome P450 Family 3
Cytochrome P450 Family 4
Cytochrome P450 Family 46
Cytochrome P450 Family 51
Cytochrome P450 Family 6
Cytochrome P450 Family 7
Cytochrome P450 Family 8
Steroid Hydroxylases
Trans-Cinnamate 4-Monooxygenase
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