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Mesh term Nucleic Acid Denaturation

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Biochemical Phenomena
Genetic Phenomena
Genetic Techniques

Description

Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.



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jenkins-FCD Prod-468 69a93cef3257f26b866d455c1d2b2d0f28382f14