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Mesh term Pregnancy-Associated Plasma Protein-A

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Metalloendopeptidases
Pregnancy Proteins

Description

A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.



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jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0