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Mesh term Receptors, LDL

Browse to parent terms:
Receptors, Lipoprotein

Description

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.


Browse to child terms:
LDL-Receptor Related Proteins
Receptors, Oxidized LDL
Receptors, Scavenger


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View this term at the NCBI website
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0