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Mesh term Histocompatibility Antigens Class I

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Histocompatibility Antigens
Membrane Glycoproteins


Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Browse to child terms:
H-2 Antigens
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
HLA-G Antigens
Hemochromatosis Protein
Histocompatibility Antigen H-2D

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