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Mesh term Chromosome Walking

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Chromosome Mapping

Description

A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.



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jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0