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Mesh term Mice, Inbred mdx

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Mice, Inbred C57BL
Mice, Mutant Strains

Description

A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.



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jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280