Mesh term Proto-Oncogene Proteins c-kit
Browse to parent terms:Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases
Receptors, Colony-Stimulating Factor
Description
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.Search for this term in our Faculty Database
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