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Mesh term BRCA1 Protein

Browse to parent terms:
Fanconi Anemia Complementation Group Proteins
Nuclear Proteins
Phosphoproteins
Transcription Factors
Tumor Suppressor Proteins

Description

The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)



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jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0