Mesh term Multiple System Atrophy
Browse to parent terms:Basal Ganglia Diseases
Movement Disorders
Neurodegenerative Diseases
Primary Dysautonomias
Description
A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)Browse to child terms:
Olivopontocerebellar Atrophies
Shy-Drager Syndrome
Striatonigral Degeneration
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