Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Mesh term In Situ Nick-End Labeling

Browse to parent terms:
Genetic Techniques

Description

An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.



Search for this term in our Faculty Database



View this term at the NCBI website
jenkins-FCD Prod-468 69a93cef3257f26b866d455c1d2b2d0f28382f14