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Mesh term Proto-Oncogene Proteins c-akt

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Intracellular Signaling Peptides and Proteins
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins

Description

Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.



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jenkins-FCD Prod-468 69a93cef3257f26b866d455c1d2b2d0f28382f14