Mesh term Presenilins
Browse to parent terms:Membrane Proteins
Description
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.Browse to child terms:
Presenilin-1
Presenilin-2
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