Mesh term CLOCK Proteins
Browse to parent terms:Basic Helix-Loop-Helix Transcription Factors
Circadian Rhythm Signaling Peptides and Proteins
Histone Acetyltransferases
Description
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.Search for this term in our Faculty Database
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