Mesh term Anaphase-Promoting Complex-Cyclosome
Browse to parent terms:Cell Cycle Proteins
Ubiquitin-Protein Ligases
Description
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.Browse to child terms:
Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
Cdc20 Proteins
Cdh1 Proteins
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