Segmental ventricular adjustments to brief periods of ischemia in the dog. Can J Physiol Pharmacol 1981 Mar;59(3):287-92
Date
03/01/1981Pubmed ID
6261904DOI
10.1139/y81-045Scopus ID
2-s2.0-0019435679 (requires institutional sign-in at Scopus site)Abstract
The changes in left ventricular segmented contractile force induced by brief periods of ischemia (15-90 s) and subsequent reperfusions were analyzed in anesthetized dogs. Segmental coronary artery occlusion (left anterior descending or left circumflex) produced a decrease in segmental ventricular function in the occluded area and an increase in contractile force in the myocardial segment away from the occluded area. With reperfusion, a transient overshoot in contractile force above preischemic control levels was observed in the occluded segment. This overshoot was shown not to be dependent on adrenergic mechanisms but appears to indicate changes in calcium permeability.
Author List
Bosnjak ZJ, Seagard JL, Zuperku EJ, Coon RL, Singh HM, Bamrah VS, Kampine JPAuthors
Zeljko Bosnjak PhD, MS Emeritus Professor in the Medicine department at Medical College of WisconsinEdward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsCalcium
Coronary Disease
Dogs
Heart Ventricles
Myocardial Contraction
Receptors, Adrenergic, beta
Time Factors
