Faculty Collaboration Database

Effects of beta-endorphin on body temperature in mice at different ambient temperatures. Peptides 1981;2(3):293-7

Date

01/01/1981

Pubmed ID

6272245

DOI

10.1016/s0196-9781(81)80122-2

Scopus ID

2-s2.0-0019818147 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

The effect of intracerebroventricular injection of beta-endorphin (beta-END) on body temperature of mice was studied at ambient temperatures (Ta) of 10 degrees, 20 degrees and 31 degrees C. Doses between 0.1 and 10.0 microgram/mouse were studied. The lower (less than 1 microgram) doses of beta-END produced a hyperthermia at all Ta's studied. The higher doses of beta-END produced hyper- or hypothermia depending on the Ta. The subcutaneous injection of naloxone (1 mg/kg) antagonized the high dose hypothermic effects, but not the hyperthermic effect of beta-END. These data suggest that there may be different receptors and/or sites of action for high and low doses of beta-END.

Author List

Bloom AS, Tseng LF

Author

Alan Bloom PhD, MA Emeritus Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Binding, Competitive
Body Temperature
Endorphins
Injections, Intraventricular
Male
Mice
Mice, Inbred ICR
Naloxone
Temperature
beta-Endorphin