Vasodilator actions of interleukin-1 in the canine coronary circulation. Basic Res Cardiol 1990;85(3):279-84
Date
05/01/1990Pubmed ID
2383221DOI
10.1007/BF01907116Scopus ID
2-s2.0-0025372986 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
The effects of intracoronary ultrapure human Interleukin-1 on the regional distribution of coronary blood flow (radioactive microspheres), contractile function (subendocardial ultrasonic length gauges) and systemic hemodynamics were studied in open-chest, anesthetized dogs (n = 7). Bolus doses of Interleukin-1 (10, 20, and 30 u) administered directly into the left anterior descending coronary artery increased coronary blood flow from 43 to 71, 80 and 87 ml/min, respectively. The increase in blood flow produced by Interleukin-1 was distributed uniformly to the subendocardium, midmyocardium, and subepicardium of the left ventricular free wall without effect on regional function or systemic hemodynamics. Indomethacin (1 mg/kg i.v.) attenuated the increase in blood flow, especially to the subepicardium. Due to the selective diminution of the Interleukin-1-mediated increase in subepicardial blood flow by indomethacin, the subendocardial to subepicardial perfusion ratio was increased by Interleukin-1 in the presence of indomethacin. The present results demonstrate that Interleukin-1 has direct coronary vasodilator actions, a portion of which is mediated by a product of cyclooxygenase metabolism.
Author List
Kenny D, McCarthy-Kenny G, Pelc LR, Cheung HS, Brooks HL, Warltier DCAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCoronary Circulation
Coronary Vessels
Dogs
Female
Hemodynamics
Indomethacin
Interleukin-1
Male
Vasodilation
