Adenosine on myocardial oxygen consumption. Br J Pharmacol 1976 Jul;57(3):409-12
Date
07/01/1976Pubmed ID
974320Pubmed Central ID
PMC1667219DOI
10.1111/j.1476-5381.1976.tb07681.xScopus ID
2-s2.0-0017080913 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
1 A 3 min intracoronary infusion of adenosine (50 mug/min) produced a significant decrease in coronary artery perfusion pressure, left ventricular systolic pressure and myocardial O2 consumption in the isolated supported heart preparation of the dog perfused at a constant coronary blood flow. Heart rate was controlled at 150, 190 or 230 beats/minute. 2 Myocardial contractile force and maximal left ventricular dp/dt were not changed by adenosine infusion. 3 The absolute decrease in myocardial O2 consumption was greater at increasing heart rates whereas the decrease in coronary artery perfusion pressure and peak left ventricular systolic pressure were similar. 4 The results suggest that the reduction in myocardial O2 consumption produced by adenosine is not related to coronary vasodilatation or to a negative chronotropic or inotropic action, but may be due to a functional shunting of blood flow from high O2 extracting regions of the myocardium to low O2 extracting ones and/or important effects on myocardial substrate utilization.
Author List
Gross GJ, Hardman HF, Warltier DCAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenosineAnimals
Blood Pressure
Coronary Circulation
Depression, Chemical
Dogs
Heart
Heart Rate
Myocardial Contraction
Myocardium
Oxygen Consumption
