Cellular responses to whitlockite. Calcif Tissue Int 1999 Nov;65(5):374-7
Date
12/14/1999Pubmed ID
10541763DOI
10.1007/s002239900716Scopus ID
2-s2.0-0032696179 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
Whitlockite crystals have been observed in both degenerating and normal articular cartilages. To determine their potential for inducing cartilage degeneration, we studied their ability to induce mitogenesis and synthesis and secretion of metalloproteases in vitro. Whitlockite crystals were found to stimulate cell proliferation and to stimulate synthesis and secretion of stromelysin and collagenase. However, they were less stimulatory than crystals that contained calcium (Ca) and phosphate without magnesium substitution for Ca. Whitlockite crystals elicit biologic cellular responses that suggest potential pathogenicity in arthritis, but are less potent than Ca phosphate crystals without magnesium.
Author List
Ryan LM, Cheung HS, LeGeros RZ, Kurup IV, Toth J, Westfall PR, McCarthy GMAuthors
Lawrence M. Ryan MD Emeritus Professor in the Medicine department at Medical College of WisconsinJeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette University
MESH terms used to index this publication - Major topics in bold
Calcium PhosphatesCell Division
Cells, Cultured
Collagenases
Fibroblasts
Humans
Immunoblotting
Matrix Metalloproteinase 3
Metalloendopeptidases
