Medical College of Wisconsin
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Platelet factor 4 enhances fibrin fiber polymerization. Thromb Res 1987 Mar 01;45(5):539-43

Date

03/01/1987

Pubmed ID

3590091

DOI

10.1016/0049-3848(87)90316-1

Scopus ID

2-s2.0-0023118095 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

In order to further examine the role of platelet secretory products on fibrin assembly, we have examined the effects of purified platelet factor 4 (PF4) on fibrin formation in vitro. The kinetics of fibrin formation and the structural properties of the resulting fibrin gel are strongly affected by PF4. In the presence of 7.6 ng/mL PF4, the fibrin fiber mass-length ratio increases from 3.5 X 10(12) daltons/cm. These results emphasize the importance of the local microenvironment in clot structure and its subsequent fate at the site of vascular injury.

Author List

Carr ME, White GC 2nd, Gabriel DA

Author

Gilbert C. White MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Fibrin
Fibrinogen
Humans
Kinetics
Nephelometry and Turbidimetry
Platelet Factor 4
Polymers
Thrombin