Cardioprotection with volatile anesthetics: mechanisms and clinical implications. Anesth Analg 2005 Jun;100(6):1584-1593
Date
05/28/2005Pubmed ID
15920178DOI
10.1213/01.ANE.0000153483.61170.0CScopus ID
2-s2.0-19044365674 (requires institutional sign-in at Scopus site) 210 CitationsAbstract
Cardiac surgery and some noncardiac procedures are associated with a significant risk of perioperative cardiac morbid events. Experimental data indicate that clinical concentrations of volatile general anesthetics protect the myocardium from ischemia and reperfusion injury, as shown by decreased infarct size and a more rapid recovery of contractile function on reperfusion. These anesthetics may also mediate protective effects in other organs, such as the brain and kidney. Recently, a number of reports have indicated that these experimentally observed protective effects may also have clinical implications in cardiac surgery. However, the impact of the use of volatile anesthetics on outcome measures, such as postoperative mortality and recovery in cardiac and noncardiac surgery, is yet to be determined.
Author List
De Hert SG, Turani F, Mathur S, Stowe DFAuthor
David F. Stowe PhD, MA, MA Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anesthetics, InhalationClinical Trials as Topic
Heart Diseases
Humans
Ischemic Preconditioning, Myocardial
Myocardial Reperfusion Injury
Postoperative Complications
