Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage 2005 Jul 15;26(4):1097-108
Date
05/12/2005Pubmed ID
15886020DOI
10.1016/j.neuroimage.2005.03.030Scopus ID
2-s2.0-20444405004 (requires institutional sign-in at Scopus site) 186 CitationsAbstract
Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with drug-induced high and craving as measures of reward and motivation. Non-treatment seeking cocaine-dependent subjects chose both when and how often i.v. cocaine administration occurred within a medically supervised SA procedure. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. Drug-induced HIGH was found to correlate negatively with activity in limbic, paralimbic, and mesocortical regions including the nucleus accumbens (NAc), inferior frontal/orbitofrontal gyrus (OFC), and anterior cingulate (AC), while CRAVING correlated positively with activity in these regions. This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system.
Author List
Risinger RC, Salmeron BJ, Ross TJ, Amen SL, Sanfilipo M, Hoffmann RG, Bloom AS, Garavan H, Stein EAAuthor
Alan Bloom PhD, MA Emeritus Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBehavior
Brain
Cocaine
Cocaine-Related Disorders
Dopamine Uptake Inhibitors
Hemodynamics
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Oxygen
Self Administration
