Halothane, tracheal compliance and upper-airway mechanoreceptors. Anesthesiology 1978 Oct;49(4):260-5
Date
10/01/1978Pubmed ID
697080DOI
10.1097/00000542-197810000-00007Scopus ID
2-s2.0-0018078181 (requires institutional sign-in at Scopus site)Abstract
This study was designed to define the effects of halothane on the compliance of the trachea. An isolated in-situ tracheal preparation was studied in 14 mongrel dogs anesthetized with pentobarbital. Compliance of the closed tracheal segment was measured with continuous intraluminal pressure recordings during repeated injections of known volumes of air: Slow-adapting neural activity observed in paratracheal branches of the recurrent laryngeal nerve accurately reflected pressure in the tracheal segment. Halothane at 0.5--4.0 per cent concentrations caused a significant (P less than 0.001) average 10 per cent increase in the compliance of the trachea. Stimulation of the efferent vagus caused a significant (P less than 0.001) average 8 per cent decrease in compliance of the trachea. After exposure to halothane, vagal stimulation still caused a significant decrease in compliance of the trachea.
Author List
Palmer SK, Zuperku EJ, Bosnjak Z, Coon RL, Kampine JPAuthors
Zeljko Bosnjak PhD, MS Emeritus Professor in the Medicine department at Medical College of WisconsinEdward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Airway ResistanceAnimals
Dogs
Electric Stimulation
Halothane
Lung Compliance
Trachea
Vagus Nerve
