Respiratory arrhythmias and airway CO2, lung receptors, and central inspiratory activity. J Appl Physiol (1985) 1986 May;60(5):1713-21
Date
05/01/1986Pubmed ID
3086282DOI
10.1152/jappl.1986.60.5.1713Scopus ID
2-s2.0-0022503891 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
The purpose of this study was to determine whether hypocapnia affects heart rate secondary to an effect on pulmonary receptors. Dogs were anesthetized and placed on cardiopulmonary bypass. Interrelationships among airway CO2, central inspiratory activity, and lung receptor effects on respiratory-related heart rate changes (respiratory arrhythmias) were studied after vagal efferent activity was increased secondary to baroreceptor stimulation. Hypocapnia, isolated to the lungs, produced an increase in the magnitude of the respiratory arrhythmias observed. Two mechanisms may produce these results. Hypocapnia affects pulmonary receptors, which 1) reflexly alter heart rate and 2) modulate breathing frequency, thus altering the dynamics of the respiratory arrhythmias that were produced. The results also suggested that the reflex increase in heart rate in response to lung inflation and the Hering-Breuer expiratory-facilitatory reflex are either produced by different pulmonary receptors or by the same pulmonary receptors but may be mediated by different central mechanisms.
Author List
Coon RL, Zuperku EJ, Kampine JPAuthor
Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adaptation, PhysiologicalAnimals
Arrhythmias, Cardiac
Carbon Dioxide
Dogs
Heart Rate
Lung
Mechanoreceptors
Pressoreceptors
Reflex
Respiration
