The evolution of DNA sequences in Escherichia coli. Philos Trans R Soc Lond B Biol Sci 1986 Jan 29;312(1154):191-204
Date
01/29/1986Pubmed ID
2870515DOI
10.1098/rstb.1986.0001Scopus ID
2-s2.0-0023058753 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
It is proposed that certain families of transposable elements originally evolved in plasmids and functioned in forming replicon fusions to aid in the horizontal transmission of non-conjugational plasmids. This hypothesis is supported by the finding that the transposable elements Tn3 and gamma delta are found almost exclusively in plasmids, and also by the distribution of the unrelated insertion sequences IS4 and IS5 among a reference collection of 67 natural isolates of Escherichia coli. Each insertion sequence was found to be present in only about one-third of the strains. Among the ten strains found to contain both insertion sequences, the number of copies of the elements was negatively correlated. With respect to IS5, approximately half of the strains containing a chromosomal copy of the insertion element also contained copies within the plasmid complement of the strain.
Author List
Hartl DL, Medhora M, Green L, Dykhuizen DEAuthor
Meetha Medhora Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Base SequenceBiological Evolution
Chromosomes, Bacterial
DNA Transposable Elements
DNA, Bacterial
Escherichia coli
Genetic Variation
Models, Genetic
Plasmids
Recombination, Genetic
