Medical College of Wisconsin
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David A. Wilcox PhD

David A. Wilcox PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology and Oncology - Pediatrics
Program: Oncology

View Curriculum Vitae

Publications (40)

  • A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia. (Koukouritaki SB, Thinn AMM, Ashworth KJ, Fang J, Slater HS, Du LM, Nguyen HTT, Pillois X, Nurden AT, Ng CJ, Di Paola J, Zhu J, Wilcox DA) Blood Adv 2023 Jul 11;7(13):3180-3191 PMID: 36884296 PMCID: PMC10338211 SCOPUS ID: 2-s2.0-85179497686 03/09/2023       1 Citation
  • NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. (Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX) Basic Res Cardiol 2022 Apr 25;117(1):24 PMID: 35469044 PMCID: PMC9119129 SCOPUS ID: 2-s2.0-85128849246 04/27/2022       5 Citations
  • Thromboelastometry assessment of hemostatic properties in various murine models with coagulopathy and the effect of factor VIII therapeutics. (Schroeder JA, Kuether EA, Fang J, Jing W, Weiler H, Wilcox DA, Montgomery RR, Shi Q) J Thromb Haemost 2021 Oct;19(10):2417-2427 PMID: 34245090 PMCID: PMC8865566 SCOPUS ID: 2-s2.0-85111140299 07/11/2021       4 Citations
  • Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner. (Korishettar AM, Nishijima Y, Wang Z, Xie Y, Fang J, Wilcox DA, Zhang DX) Br J Pharmacol 2021 Feb;178(3):709-725 PMID: 33184836 PMCID: PMC9121782 SCOPUS ID: 2-s2.0-85098221966 11/14/2020       5 Citations
  • Gene therapy for platelet disorders (Wilcox DA) Platelets 1 January 2019:1191-1205 SCOPUS ID: 2-s2.0-85081898981 01/01/2019       1 Citation
  • Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation. (Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, Fang J, Wilcox DA, Zhang DX) J Biol Chem 2018 Apr 06;293(14):5307-5322 PMID: 29462784 PMCID: PMC5892583 SCOPUS ID: 2-s2.0-85045077479 02/21/2018       48 Citations
  • A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. (Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E) Blood 2016 Jun 09;127(23):2791-803 PMID: 27084890 PMCID: PMC5016734 SCOPUS ID: 2-s2.0-84993990664 04/17/2016       155 Citations
  • Megakaryocyte- and megakaryocyte precursor-related gene therapies. (Wilcox DA) Blood 2016 Mar 10;127(10):1260-8 PMID: 26787735 PMCID: PMC4786835 SCOPUS ID: 2-s2.0-84960889147 01/21/2016       13 Citations
  • Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity. (Ristow LC, Bonde M, Lin YP, Sato H, Curtis M, Wesley E, Hahn BL, Fang J, Wilcox DA, Leong JM, Bergström S, Coburn J) Cell Microbiol 2015 Jul;17(7):1021-36 PMID: 25604835 PMCID: PMC4478124 SCOPUS ID: 2-s2.0-84931571353 01/22/2015       38 Citations
  • In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infection. (Schroeder JA, Chen Y, Fang J, Wilcox DA, Shi Q) J Thromb Haemost 2014 Aug;12(8):1283-93 PMID: 24931217 PMCID: PMC4127102 SCOPUS ID: 2-s2.0-84905667071 06/17/2014       30 Citations
  • High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. (Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P) Blood 2014 Jan 30;123(5):753-7 PMID: 24335497 PMCID: PMC3907760 SCOPUS ID: 2-s2.0-84897024164 12/18/2013       49 Citations
  • Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A. (Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Raymer RA, Fang J, Koukouritaki SB, Jacobi PM, Hawkins TB, Cornetta K, Shi Q, Wilcox DA) Nat Commun 2013;4:2773 PMID: 24253479 PMCID: PMC3868233 SCOPUS ID: 2-s2.0-84893419411 11/21/2013       97 Citations
  • Gene Therapy for Platelet Disorders (Wilcox DA) Platelets 2013:1313-1327 SCOPUS ID: 2-s2.0-84882670055 08/27/2013    
  • Glanzmann thrombasthenia: state of the art and future directions. (Nurden AT, Pillois X, Wilcox DA) Semin Thromb Hemost 2013 Sep;39(6):642-55 PMID: 23929305 PMCID: PMC4011384 SCOPUS ID: 2-s2.0-84883249514 08/10/2013       79 Citations
  • Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry. (Zheng X, Zinkevich NS, Gebremedhin D, Gauthier KM, Nishijima Y, Fang J, Wilcox DA, Campbell WB, Gutterman DD, Zhang DX) J Am Heart Assoc 2013 Apr 25;2(3):e000080 PMID: 23619744 PMCID: PMC3698766 SCOPUS ID: 2-s2.0-84887401738 04/27/2013       67 Citations
  • C560Rβ3 caused platelet integrin αII b β3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality. (Fang J, Nurden P, North P, Nurden AT, Du LM, Valentin N, Wilcox DA) J Thromb Haemost 2013 Jun;11(6):1163-71 PMID: 23551977 PMCID: PMC3702628 SCOPUS ID: 2-s2.0-84883256631 04/05/2013       18 Citations
  • Lentivirus-mediated platelet gene therapy of murine hemophilia A with pre-existing anti-factor VIII immunity. (Kuether EL, Schroeder JA, Fahs SA, Cooley BC, Chen Y, Montgomery RR, Wilcox DA, Shi Q) J Thromb Haemost 2012 Aug;10(8):1570-80 PMID: 22632092 PMCID: PMC3419807 SCOPUS ID: 2-s2.0-84864333652 05/29/2012       88 Citations
  • Gene Therapy for Platelet Disorders (Wilcox DA) Platelets, Third Edition 1 January 2012:1313-1327 SCOPUS ID: 2-s2.0-85148920038 01/01/2012    
  • Platelet gene therapy improves hemostatic function for integrin alphaIIbbeta3-deficient dogs. (Fang J, Jensen ES, Boudreaux MK, Du LM, Hawkins TB, Koukouritaki SB, Cornetta K, Wilcox DA) Proc Natl Acad Sci U S A 2011 Jun 07;108(23):9583-8 PMID: 21606353 PMCID: PMC3111318 SCOPUS ID: 2-s2.0-79959329020 05/25/2011       50 Citations
  • Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. (Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ) Blood 2011 May 05;117(18):4946-52 PMID: 21368290 PMCID: PMC3100701 SCOPUS ID: 2-s2.0-79955964309 03/04/2011       109 Citations
  • TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. (Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX) Am J Physiol Heart Circ Physiol 2010 Feb;298(2):H466-76 PMID: 19966050 PMCID: PMC2822567 SCOPUS ID: 2-s2.0-74949090413 12/08/2009       252 Citations
  • Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia. (Ghevaert C, Wilcox DA, Fang J, Armour KL, Clark MR, Ouwehand WH, Williamson LM) J Clin Invest 2008 Aug;118(8):2929-38 PMID: 18654666 PMCID: PMC2483683 SCOPUS ID: 2-s2.0-48749129395 07/26/2008       45 Citations
  • Syngeneic transplantation of hematopoietic stem cells that are genetically modified to express factor VIII in platelets restores hemostasis to hemophilia A mice with preexisting FVIII immunity. (Shi Q, Fahs SA, Wilcox DA, Kuether EL, Morateck PA, Mareno N, Weiler H, Montgomery RR) Blood 2008 Oct 01;112(7):2713-21 PMID: 18495954 PMCID: PMC2556608 SCOPUS ID: 2-s2.0-53449090226 05/23/2008       84 Citations
  • Gene therapy for platelet disorders (Wilcox DA, White GC) Platelets 2007:1313-1325 SCOPUS ID: 2-s2.0-84884760773 12/01/2007    
  • Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A. (Shi Q, Wilcox DA, Fahs SA, Fang J, Johnson BD, DU LM, Desai D, Montgomery RR) J Thromb Haemost 2007 Feb;5(2):352-61 PMID: 17269937 SCOPUS ID: 2-s2.0-33846453333 02/03/2007       115 Citations
  • Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies. (Shi Q, Wilcox DA, Fahs SA, Weiler H, Wells CW, Cooley BC, Desai D, Morateck PA, Gorski J, Montgomery RR) J Clin Invest 2006 Jul;116(7):1974-82 PMID: 16823491 PMCID: PMC1483176 SCOPUS ID: 2-s2.0-33745864802 07/11/2006       151 Citations
  • Gene therapy for platelet disorders (Wilcox DA, White GC) Platelets, Second Edition 1 January 2006:1313-1325 SCOPUS ID: 2-s2.0-85148811128 01/01/2006    
  • Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. (Fang J, Hodivala-Dilke K, Johnson BD, Du LM, Hynes RO, White GC 2nd, Wilcox DA) Blood 2005 Oct 15;106(8):2671-9 PMID: 15972454 PMCID: PMC1895311 SCOPUS ID: 2-s2.0-27144537145 06/24/2005       82 Citations
  • Targeting platelet GPIbalpha transgene expression to human megakaryocytes and forming a complete complex with endogenous GPIbbeta and GPIX. (Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR) J Thromb Haemost 2004 Nov;2(11):1989-97 PMID: 15550031 SCOPUS ID: 2-s2.0-13244262627 11/20/2004       33 Citations
  • Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII. (Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White GC 2nd, Montgomery RR) J Thromb Haemost 2003 Dec;1(12):2477-89 PMID: 14675082 SCOPUS ID: 2-s2.0-1542544992 12/17/2003       50 Citations
  • Correction of a large animal model of type I Glanzmann's thrombasthenia by nonmyeloablative bone marrow transplantation. (Niemeyer GP, Boudreaux MK, Goodman-Martin SA, Monroe CM, Wilcox DA, Lothrop CD Jr) Exp Hematol 2003 Dec;31(12):1357-62 PMID: 14662345 SCOPUS ID: 2-s2.0-0345097306 12/10/2003       21 Citations
  • Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia. (Wilcox DA, White GC 2nd) J Thromb Haemost 2003 Nov;1(11):2300-11 PMID: 14629461 SCOPUS ID: 2-s2.0-4444281228 11/25/2003       32 Citations
  • Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. (Yarovoi HV, Kufrin D, Eslin DE, Thornton MA, Haberichter SL, Shi Q, Zhu H, Camire R, Fakharzadeh SS, Kowalska MA, Wilcox DA, Sachais BS, Montgomery RR, Poncz M) Blood 2003 Dec 01;102(12):4006-13 PMID: 12881300 SCOPUS ID: 2-s2.0-10744231807 07/26/2003       128 Citations
  • Expression of human factor VIII under control of the platelet-specific alphaIIb promoter in megakaryocytic cell line as well as storage together with VWF. (Shi Q, Wilcox DA, Fahs SA, Kroner PA, Montgomery RR) Mol Genet Metab 2003 May;79(1):25-33 PMID: 12765843 SCOPUS ID: 2-s2.0-0038522536 05/27/2003       43 Citations
  • Megakaryocyte-targeted synthesis of the integrin beta(3)-subunit results in the phenotypic correction of Glanzmann thrombasthenia. (Wilcox DA, Olsen JC, Ishizawa L, Bray PF, French DL, Steeber DA, Bell WR, Griffith M, White GC 2nd) Blood 2000 Jun 15;95(12):3645-51 PMID: 10845892 SCOPUS ID: 2-s2.0-0034660309 06/14/2000       52 Citations
  • Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. (Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S) J Cell Biol 1999 Dec 27;147(7):1419-30 PMID: 10613901 PMCID: PMC2174239 SCOPUS ID: 2-s2.0-0033611139 12/30/1999       78 Citations
  • Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells. (Wilcox DA, Olsen JC, Ishizawa L, Griffith M, White GC 2nd) Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9654-9 PMID: 10449749 PMCID: PMC22265 SCOPUS ID: 2-s2.0-0033578285 08/18/1999       52 Citations
  • Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. (Wilcox DA, Paddock CM, Lyman S, Gill JC, Newman PJ) J Clin Invest 1995 Apr;95(4):1553-60 PMID: 7706461 PMCID: PMC295643 SCOPUS ID: 2-s2.0-0028951764 04/01/1995       66 Citations
  • A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex. (Wilcox DA, Wautier JL, Pidard D, Newman PJ) J Biol Chem 1994 Feb 11;269(6):4450-7 PMID: 7508443 SCOPUS ID: 2-s2.0-0028071221 02/11/1994       83 Citations
  • Developing neural crest cells in culture: correlation of cytochrome oxidase activity with SSEA-1 and dopamine-beta-hydroxylase immunoreactivity. (Liu S, Wilcox DA, Sieber-Blum M, Wong-Riley M) Brain Res 1990 Dec 10;535(2):271-80 PMID: 1981490 SCOPUS ID: 2-s2.0-0025203732 12/10/1990       6 Citations
    • Last update: 04/18/2024