Medical College of Wisconsin
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Qing-song Liu PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development


  • Endocannabinoid signaling in the etiology and treatment of major depressive illness. (Hillard CJ, Liu QS) Curr Pharm Des 2014;20(23):3795-811 PMID 24180398
  • CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. (Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, Bayer KU, Liu QS) Neuropsychopharmacology 2014 Mar;39(4):989-99 PMID 24154664
  • Melatonin protects against amyloid-β-induced impairments of hippocampal LTP and spatial learning in rats. (Liu XJ, Yuan L, Yang D, Han WN, Li QS, Yang W, Liu QS, Qi JS) Synapse 2013 Sep;67(9):626-36 PMID 23620224
  • Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis. (Yu F, Zhong P, Liu X, Sun D, Gao HQ, Liu QS) Neuropsychopharmacology 2013 Jun;38(7):1308-21 PMID 23348064
  • Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. (Zhong P, Wang W, Yu F, Nazari M, Liu X, Liu QS) Neuropsychopharmacology 2012 Oct;37(11):2377-87 PMID 22713909
  • Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. (Han J, Kesner P, Metna-Laurent M, Duan T, Xu L, Georges F, Koehl M, Abrous DN, Mendizabal-Zubiaga J, Grandes P, Liu Q, Bai G, Wang W, Xiong L, Ren W, Marsicano G, Zhang X) Cell 2012 Mar 2;148(5):1039-50 PMID 22385967
  • Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. (Pan B, Wang W, Zhong P, Blankman JL, Cravatt BF, Liu QS) J Neurosci 2011 Sep 21;31(38):13420-30 PMID 21940435
  • Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. (Zhong P, Pan B, Gao XP, Blankman JL, Cravatt BF, Liu QS) J Physiol 2011 Oct 15;589(Pt 20):4847-55 PMID 21911610
  • Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects. (Pan B, Zhong P, Sun D, Liu QS) J Neurosci 2011 Aug 3;31(31):11244-55 PMID 21813685
  • Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. (Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ) J Neurosci 2011 Jul 20;31(29):10506-15 PMID 21775596
  • Excitatory-inhibitory imbalance in hypoglossal neurons during the critical period of postnatal development in the rat. (Gao XP, Liu QS, Liu Q, Wong-Riley MT) J Physiol 2011 Apr 15;589(Pt 8):1991-2006 PMID 21486774
  • Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. (Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF) Nat Neurosci 2010 Sep;13(9):1113-9 PMID 20729846
  • Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. (Wang W, Sun D, Pan B, Roberts CJ, Sun X, Hillard CJ, Liu QS) Neuropsychopharmacology 2010 Oct;35(11):2249-61 PMID 20664582
  • Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. (Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS) J Pharmacol Exp Ther 2009 Nov;331(2):591-7 PMID 19666749
  • D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Dec 24;28(52):14018-30 PMID 19109485
  • Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Feb 6;28(6):1385-97 PMID 18256258
  • Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. (Liu QS, Xu Q, Kang J, Nedergaard M) Neuron Glia Biol 2004 Nov;1(4):307-16 PMID 16755304
  • BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal. (Pu L, Liu QS, Poo MM) Nat Neurosci 2006 May;9(5):605-7 PMID 16633344
  • Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons. (Liu QS, Pu L, Poo MM) Nature 2005 Oct 13;437(7061):1027-31 PMID 16222299
  • P2X7 receptor inhibition improves recovery after spinal cord injury. (Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M) Nat Med 2004 Aug;10(8):821-7 PMID 15258577
  • Astrocyte-mediated activation of neuronal kainate receptors. (Liu QS, Xu Q, Arcuino G, Kang J, Nedergaard M) Proc Natl Acad Sci U S A 2004 Mar 2;101(9):3172-7 PMID 14766987
  • Signaling at the gliovascular interface. (Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M) J Neurosci 2003 Oct 8;23(27):9254-62 PMID 14534260
  • Potentiation of alpha7-containing nicotinic acetylcholine receptors by select albumins. (Conroy WG, Liu QS, Nai Q, Margiotta JF, Berg DK) Mol Pharmacol 2003 Feb;63(2):419-28 PMID 12527814
  • Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways. (Hu M, Liu QS, Chang KT, Berg DK) Mol Cell Neurosci 2002 Dec;21(4):616-25 PMID 12504594
  • beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. (Liu Q, Kawai H, Berg DK) Proc Natl Acad Sci U S A 2001 Apr 10;98(8):4734-9 PMID 11274373
  • Selective modulation of excitatory transmission by mu-opioid receptor activation in rat supraoptic neurons. (Liu QS, Han S, Jia YS, Ju G) J Neurophysiol 1999 Dec;82(6):3000-5 PMID 10601435
  • Actin filaments and the opposing actions of CaM kinase II and calcineurin in regulating alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. (Liu Qs, Berg DK) J Neurosci 1999 Dec 1;19(23):10280-8 PMID 10575025
  • Extracellular calcium regulates responses of both alpha3- and alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. (Liu QS, Berg DK) J Neurophysiol 1999 Sep;82(3):1124-32 PMID 10482732
  • Kainate acts at presynaptic receptors to increase GABA release from hypothalamic neurons. (Liu QS, Patrylo PR, Gao XB, van den Pol AN) J Neurophysiol 1999 Aug;82(2):1059-62 PMID 10444697
  • Grants and Awards

  • Mechanistic Studies of Phosphodiesterase Inhibitors in Cocaine Addiction (#9208586 04/15/2014 - 01/31/2019) Sponsor: NIH Drug Abuse
  • Mechanistic studies of 2-AG inactivation inhibitors as antidepressants (#9207541 06/11/2012 - 08/31/2014) Sponsor: NIH Mental Health
  • Advancing New Discoveries in Translational Research Through the Collaborative and Pilot Studies Program (#9520196 04/01/2011 - 03/31/2016) PI of Antidepressant Actions of Monoacylglycerol Lipase Inhibitor JZL184 (#5520201)
  • Program for the Study of Neuronal Synaptic Plasticity in Health and Illness (#9520217 01/01/2012 - 12/31/2016) PI of PDE Inhibitor-Induced Activation of Epac Signaling in Cocaine Addiction (#5520294)