CURRICULUM VITAE
Olena Isaeva PhD
Olena Isaeva PhD
Assistant Professor
Department of Cell Biology, Neurobiology and Anatomy
Department of Cell Biology, Neurobiology and Anatomy
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-8646 |
Email: oisaeva@mcw.edu |
EDUCATION: |
1989 - 1994 MS, Dnepropetrovsk State University, Dnypro, Ukraine |
1995 - 1998 PhD, Bogomoletz Institute of Physiology, Kyiv, Ukraine |
2015 - 2016 Doctor of Science, Bogomoletz Institute of Physiology, Kyiv, Ukraine |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2001 - 2003 Postdoctoral Fellow, Pharmacology and Physiology, New Jersey Medical School, Newark, NJ |
2004 - 2006 Postdoctoral Fellow, Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH |
2018 Postdoctoral Fellow, Physiology, Medical College of Wisconsin, Milwaukee, WI |
FACULTY APPOINTMENTS: |
2010 - 2013 Adjunct Assistant Professor, Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH |
2010 - 2018 Senior/Leading Scientific Researcher, Cellular Membranology, Bogomoletz Institute of Physiology, Kyiv, Ukraine |
10/2018 - 09/2021 Visiting Assistant Professor, Physiology, Medical College of Wisconsin, Milwaukee, WI |
09/2021 - Present Assistant Professor, Cell Biology, Neurobiology
and Anatomy, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
1996 President of Ukraine Scholarship for Talented Young Scientists, Government Fund of Ukraine |
2000 Scholarship against BrainDrain, International Brain Research Organization |
2008 Travel Award, The International League Against Epilepsy |
2012 Travel Award , The International League Against Epilepsy |
2013 State Prize of Ukraine in Science and Technology, Government Fund of Ukraine |
2017 President of Ukraine Award for Young
Doctors of Science, State Fund for Fundamental Research of Ukraine |
2019 Renal Section Research Recognition Award, American Physiological Society |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
1999 - Present Ukrainian Society for Neuroscience (member) |
2001 - 2003 American Biophysical Society (member) |
2001 - Present American Society for Neuroscience (member) |
2004 - 2006 American Epilepsy Society (member) |
2007 - Present The Federation of European Neuroscience Societies (member) |
2019 - 2021 American Physiological Society (member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2021 - Present Frontiers in Physiology (Renal and Epithelial Physiology) |
Journal Review |
Scientific Reports; Frontiers in Neuroanatomy; Frontiers in Neurology; Experimental Neurology; PloS ONE; Brain Research Bulletin; Neurological Research; Neuroscience Letters
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INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2010 Reviewer, Committee for Medical and Biological Sciences, Czech Science Foundation |
2017 - 2018 Program Secretary, Executive Committee, Ukrainian Society for Neuroscience |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Isaeva E, The role of endogenous neuraminidase in regulation of neuronal activity of rat hippocampus, Department of General Physiology Seminar, Bogomoletz Institute of Physiology, Kiev, Ukraine, 2009 |
Isaeva E, Regulation of neuronal excitability, synaptogenesis, and synaptic plasticity by sialic acids, Invited Lecture, Birla Institute of Technology & Science, Pilani-Hyderabad, India, 2012 |
Isaeva E, Long-term consequences of neonatal epileptic seizures on neuronal activity of rat cerebral cortex, Department of General Physiology Seminar, Bogomoletz Institute of Physiology, Kiev Ukraine, 2012 |
Isaeva E, The role of thrombin receptor in seizures and epilepsy associated with blood-brain barrier dysfunction, Ukrainian Society for Neuroscience Meeting, Bogomoletz Institute of Physiology, Kiev, Ukraine, 2017 |
Isaeva E, Charged nanoparticles as regulators of excitability of nerve cells: a new approach for epilepsy treatment, NanoBSR meeting, Uppsala University, Uppsala, Sweden, 2017 |
Isaeva E, Drug discovery and development process, First-Year Student Ceremony, Invited Lecture, Igor Sikorsky Kyiv Polytechnic Institute, Kiev Ukraine, 2018 |
Regional |
Isaeva E, Fedoriuk M, Bohovyk R, Levchenko V, Palygin O, Staruschenko A., New vibro-dissociation method for isolation of defined nephron segments and small renal vessels, Experimental Biology, Orlando, FL, 2019 |
Local |
Isaeva E, Contribution of Protease-Activated Receptor 1 to acquired epilepsy and its behavioral complications, Department Seminar, Medical College of Wisconsin, Milwaukee, WI, 2019 |
Olena Isaeva, New insight into paclitaxel-induced mechanical hypersensitivity:
focus on the epidermal Piezo1 channel, Pain Collaboration Conversations, Medical College of Wisconsin, 2023 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Local |
Olena isaeva, New insight into paclitaxel-induced mechanical hypersensitivity: focus on the epidermal Piezo1 channel, NRC Collaboration Conversations: Pain, Medical College of Wisconsin, 06/29/2023 |
MCW TEACHING ACTIVITIES: |
Graduate Student Education |
11/18/2022 Lecture: Representation of Pain in the Brain. |
01/03/2024 - 02/21/2024 Lecture: Calcium Channels (Course: Ion Channels and Signal Transduction) |
EXTRAMURAL TEACHING: |
Medical Student Education |
2016 - 2018 Biology and Medicine Institute Science Educational Center of Taras Shevchenko National University of Kyiv, Ukraine, Course: Mechanisms of cell regulation |
2017 Biology and Medicine Institute Science Educational Center of Taras Shevchenko National University of Kyiv, Ukraine, Course: Molecular and systemic mechanisms of action of medicinal products |
2018 Biology and Medicine Institute Science Educational Center of Taras Shevchenko National University of Kyiv, Ukraine, Course: Neurobiophysics |
Graduate Student Education |
2017 - 2018 Bogomoletz Institute of Physiology, Kiev, Ukraine, Course: Experimental epilepsy studies |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
05/31/2023 - 08/04/2023 Megan Prahl, SPUR student mentorship, Medical College of Wisconsin, presentation at the Summer Program Symposium |
05/29/2024 - 08/02/2024 Vivien Blecking, SPUR student mentorship, Medical College of Wisconsin, presentation at the Summer Program Symposium |
Graduate Students |
PhD Committees |
01/2022 - Present Christina Mecca, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
09/2013 - 06/2014 Alexey Komarov, academic mentorship, Moscow Institute of Physics and Technology |
09/2014 - 06/2016 Anastasia Vlasyuk, academic mentorship, Moscow Institute of Physics and Technology |
09/2014 - 06/2016 Ganna Semenets, academic mentorship, Biology and Medicine Institute Science Educational Center of Taras Shevchenko National University of Kyiv, Ukraine |
09/2016 - 06/2018 Hanna Goncharova, academic mentorship, Biology and Medicine Institute Science Educational Center of Taras Shevchenko National University of Kyiv, Ukraine |
09/2017 - 06/2018 Maria Klymenko, instructor, Biology and Medicine Institute Science Educational Center of Taras Shevchenko National University of Kyiv, Ukraine |
Medical Students |
07/2014 - 06/2017 Ahmad Dzhuma, academic mentorship, Bogomolets National Medical University |
Graduate Students |
PhD Students Advised |
11/2010 - 12/2012 Alina Savotchenko, Bogomoletz Institute of Physiology, Kiev, Ukraine |
11/2016 - 07/2020 Marharyta Semenikhina, Bogomoletz Institute of Physiology, Kiev, Ukraine |
PhD Committees |
2011 - 2013 Amanda Hernan, Geisel School of Medicine at Dartmouth |
Students Advised |
05/2016 - 10/2018 Oleksii Lunko, Bogomoletz Institute of Physiology, Kiev, Ukraine |
11/2018 - 09/2023 Oksana Nikolaienko, Bogomoletz Institute of Physiology, Kiev, Ukraine |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Vasil'yev DV, Isaeva EV, Fedulova SA, Veselovskii NS. Potassium channel blocker-induced presynaptic modulation of inhibitory synaptic transmission in hippocampal neurons of rats Neurophysiology. July/October 1998;30(4-5):275-278. |
2. Isaeva EV, Fedulova SA, Veselovskii NS. Voltage-dependent calcium channels in cultivated neurons of the rat hippocampus Neurophysiology. July/October 1998;30(4-5):297-300. |
3. Isaeva EV, Sidorenko VG, Fedulova SA, Veselovskii NS. Evoked inhibitory postsynaptic currents in the dynamics of development of cultured hippocampal neurons of rats Neurophysiology. September/October 1999;31(5):304-309. |
4. Isaeva EV. Effect of nifedipine in high concentrations on inhibitory synaptic transmission Neurophysiology. January/February 1999;31(1):53-55. |
5. Fedulova SA, Vasilyev DV, Isaeva EV, Romanyuk SG, Veselovsky NS. Possibility of multiquantal transmission at single inhibitory synapse in cultured rat hippocampal neurons. Neuroscience. 1999;92(4):1217-30. |
6. Fedulova SA, Isaeva EV, Veselovsky NS. Involvement of different types of Ca<sup>2+</sup> currents in the control of the efficiency of inhibitory synaptic transmission between cultured hippocampal neurons Neurophysiology. 2000;32(6):355-359. |
7. Isaeva EV, Shirokova N. Metabolic regulation of Ca2+ release in permeabilized mammalian skeletal muscle fibres. J Physiol. 2003 Mar 01;547(Pt 2):453-62. PMCID: PMC2342647 |
8. Isaeva EV, Shkryl VM, Shirokova N. Mitochondrial redox state and Ca2+ sparks in permeabilized mammalian skeletal muscle. J Physiol. 2005 Jun 15;565(Pt 3):855-72. PMCID: PMC1464560 |
9. Isaev D, Isaeva E, Khazipov R, Holmes GL. Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro. J Neurophysiol. 2005 Oct;94(4):2987-92. |
10. Isaeva E, Isaev D, Khazipov R, Holmes GL. Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. Eur J Neurosci. 2006 Mar;23(6):1559-66. |
11. Isaev D, Isaeva E, Khazipov R, Holmes GL. Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus. Hippocampus. 2007;17(3):210-9. |
12. Isaev D, Isaeva E, Shatskih T, Zhao Q, Smits NC, Shworak NW, Khazipov R, Holmes GL. Role of extracellular sialic acid in regulation of neuronal and network excitability in the rat hippocampus. J Neurosci. 2007 Oct 24;27(43):11587-94. PMCID: PMC6673228 |
13. Isaeva E, Isaev D, Holmes GL. Anesthetic and postanesthetic effects of isoflurane on neuronal activity in the rat hippocampus Neurophysiology. 2007;39(4-5):325-326. |
14. Isaeva EV. Effects of isoflurane on hippocampal seizures at immature rats in vivo. Fiziol Zh (1994). 2008;54(5):40-5. |
15. Isaeva EV. Mechanism of antiseizure effect of isoflurane in the immature rat hippocampus. Fiziol Zh (1994). 2009;55(1):57-60. |
16. Isaeva E, Isaev D, Khazipov R, Holmes GL. Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex. Epilepsy Res. 2009 Dec;87(2-3):286-9. PMCID: PMC2788005 |
17. Savrasova AV, Lushnikova IV, Isaeva EV, Skibo GG, Isaev DS, Kostyuk PG. The effect of neuraminidase blocker on gabazine-induced seizures in rat hippocampus. Fiziol Zh (1994). 2010;56(4):14-8. |
18. Isaeva E, Isaev D, Savrasova A, Khazipov R, Holmes GL. Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. Eur J Neurosci. 2010 Apr;31(8):1446-55. PMCID: PMC3148010 |
19. Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D. Blockade of endogenous neuraminidase leads to an increase of neuronal excitability and activity-dependent synaptogenesis in the rat hippocampus. Eur J Neurosci. 2010 Dec;32(11):1889-96. |
20. Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D. Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus Pharmacological Reports. 2011;63(3):840-844. |
21. Isaeva EV, Isaev DS. Anaesthetic and postanaesthetic effect of isoflurane on the multiple-unit activity of the immature rat hippocampus. Fiziol Zh (1994). 2011;57(1):17-20. |
22. Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 2011 Mar;52(3):e12-5. PMCID: PMC3265164 |
23. Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D. Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus. Pharmacol Rep. 2011;63(3):840-4. |
24. Isaev D, Ivanchick G, Khmyz V, Isaeva E, Savrasova A, Krishtal O, Holmes GL, Maximyuk O. Surface charge impact in low-magnesium model of seizure in rat hippocampus. J Neurophysiol. 2012 Jan;107(1):417-23. PMCID: PMC3349697 |
25. Isaev DS, Isaeva EV, Savrasova AV, Holmes GL. Effect of neonatal epileptic attacks on the activity of neocortical neurons Neurophysiology. November 2011;43(3):227-228. |
26. Talnov AN, Isaeva E, Savotchenko AV, Dovgalets GV, Ochoa JG, Holmes GL, Isaev D. Electrolyte therapy reduces spike-and-wave discharges in the WAG/Rij rat model of absence epilepsy. Epilepsy Behav. 2012 Aug;24(4):399-402. PMCID: PMC3408819 |
27. Isaeva E, Hernan A, Isaev D, Holmes GL. Thrombin facilitates seizures through activation of persistent sodium current. Ann Neurol. 2012 Aug;72(2):192-8. PMCID: PMC3430976 |
28. Hernan AE, Holmes GL, Isaev D, Scott RC, Isaeva E. Altered short-term plasticity in the prefrontal cortex after early life seizures. Neurobiol Dis. 2013 Feb;50:120-6. PMCID: PMC3534893 |
29. Isaeva E, Isaev D, Holmes GL. Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex. Epilepsy Res. 2013 Sep;106(1-2):280-3. PMCID: PMC3758912 |
30. Hernan AE, Alexander A, Jenks KR, Barry J, Lenck-Santini PP, Isaeva E, Holmes GL, Scott RC. Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits. Neurobiol Dis. 2014 Mar;63:25-34. PMCID: PMC4397918 |
31. Lunko O, Isaev D, Maximyuk O, Ivanchick G, Sydorenko V, Krishtal O, Isaeva E. Persistent sodium current properties in hippocampal CA1 pyramidal neurons of young and adult rats. Neurosci Lett. 2014 Jan 24;559:30-3. |
32. Isaeva EV, Lunko OO, Romano AK, Isaev DS. [EFFECT OF NEONATAL SEIZURES ON THE SYNAPTIC PLASTICITY OF RAT SOMATOSENSORY CORTEX]. Fiziol Zh (1994). 2015;61(6):11-6. |
33. Voytenko LP, Lushnikova IV, Savotchenko AV, Isaeva EV, Skok MV, Lykhmus OY, Patseva MA, Skibo GG. Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation. Brain Res. 2015 Aug 07;1616:134-45. |
34. Lunko OO, Isaev DS, Krishtal OO, Isaeva EV. Thrombin modulates persistent sodium current in CA1 pyramidal neurons of young and adult rat hippocampus. Fiziol Zh (1994). 2015;61(4):5-10. |
35. Isaeva E, Romanov A, Holmes GL, Isaev D. Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis. Epilepsy Res. 2015 Feb;110:166-70. PMCID: PMC4361808 |
36. Savotchenko A, Romanov A, Isaev D, Maximyuk O, Sydorenko V, Holmes GL, Isaeva E. Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus. Neural Plast. 2015;2015:908190. PMCID: PMC4329761 |
37. Buta A, Maximyuk O, Kovalskyy D, Sukach V, Vovk M, Ievglevskyi O, Isaeva E, Isaev D, Savotchenko A, Krishtal O. Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction. J Med Chem. 2015 Jun 11;58(11):4449-61. |
38. Isaev D, Lushnikova I, Lunko O, Zapukhliak O, Maximyuk O, Romanov A, Skibo GG, Tian C, Holmes GL, Isaeva E. Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis. Neurobiol Dis. 2015 Jun;78:68-76. PMCID: PMC4682556 |
39. Zapukhliak OS, Kachanovska VO, Isaeva EV, Netsyk OV, Isaev DS. Surface charge impact in nonsynaptic model of epilepsy in rat hippocampus. Fiziol Zh (1994). 2016;62(2):35-40. |
40. Sydorenko VG, Komarov OS, Sushko BS, Romanov AK, Isaeva EV, Isaev DS. Modulation of 4-aminopyridine-induced neuronal activity and local pO(2)in rat hippocampal slices by changing the flow rate of the superfusion medium. Fiziol Zh (1994). 2016;62(4):3-11. |
41. Ievglevskyi O, Isaev D, Netsyk O, Romanov A, Fedoriuk M, Maximyuk O, Isaeva E, Akaike N, Krishtal O. Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy. Philos Trans R Soc Lond B Biol Sci. 2016 Aug 05;371(1700). PMCID: PMC4938031 |
42. Bogovyk R, Lunko O, Fedoriuk M, Isaev D, Krishtal O, Holmes GL, Isaeva E. Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus. Epilepsy Behav. 2017 Feb;67:66-69. |
43. Semenikhina M, Bogovyk R, Fedoriuk M, Nikolaienko O, Al Kury LT, Savotchenko A, Krishtal O, Isaeva E. Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus. Neurosci Lett. 2019 Jan 23;692:64-68. |
44. Ilatovskaya DV, Levchenko V, Pavlov TS, Isaeva E, Klemens CA, Johnson J, Liu P, Kriegel AJ, Staruschenko A. Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). EBioMedicine. 2019 Feb;40:663-674. PMCID: PMC6413684 |
45. Isaeva E, Fedoriuk M, Bohovyk R, Klemens CA, Khedr S, Golosova D, Levchenko V, El-Meanawy A, Palygin O, Staruschenko A. Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys. Am J Physiol Renal Physiol. 2019 Nov 01;317(5):F1398-F1403. PMCID: PMC6879945 |
46. Romanov A, Isaeva E. Experimental models in the study of the mechanisms and consequences of epileptic seizures in neonatal period of life Fiziologichnyi Zhurnal. 2020;66(2-3):93-100. |
47. Pavlov TS, Palygin O, Isaeva E, Levchenko V, Khedr S, Blass G, Ilatovskaya DV, Cowley AW Jr, Staruschenko A. NOX4-dependent regulation of ENaC in hypertension and diabetic kidney disease. FASEB J. 2020 Oct;34(10):13396-13408. PMCID: PMC7722042 |
48. Golosova D, Palygin O, Bohovyk R, Klemens CA, Levchenko V, Spires DR, Isaeva E, El-Meanawy A, Staruschenko A. Role of opioid signaling in kidney damage during the development of salt-induced hypertension. Life Sci Alliance. 2020 Dec;3(12). PMCID: PMC7556751 |
49. Nikolaienko O, Isaeva E, Levchenko V, Palygin O, Staruschenko A. Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2020 Dec 01;319(6):R684-R689. PMCID: PMC7792816 |
50. Manis AD, Palygin O, Isaeva E, Levchenko V, LaViolette PS, Pavlov TS, Hodges MR, Staruschenko A. Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat. JCI Insight. 2021 Jan 11;6(1). PMCID: PMC7821607 |
51. Bohovyk R, Fedoriuk M, Isaeva E, Shevchuk A, Palygin O, Staruschenko A. Scanning ion conductance microscopy of live human glomerulus. J Cell Mol Med. 2021 May;25(9):4216-4219. PMCID: PMC8093965 |
52. Spires DR, Palygin O, Levchenko V, Isaeva E, Klemens CA, Khedr S, Nikolaienko O, Kriegel A, Cheng X, Yeo JY, Joe B, Staruschenko A. Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats. Physiol Genomics. 2021 Jun 01;53(6):223-234. PMCID: PMC8285576 |
53. Palygin O, Klemens CA, Isaeva E, Levchenko V, Spires DR, Dissanayake LV, Nikolaienko O, Ilatovskaya DV, Staruschenko A. Characterization of purinergic receptor 2 signaling in podocytes from diabetic kidneys. iScience. 2021 Jun 25;24(6):102528. PMCID: PMC8188476 |
54. Hyndman KA, Isaeva E, Palygin O, Mendoza LD, Rodan AR, Staruschenko A, Pollock JS. Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis. Physiol Rep. 2021 Oct;9(20):e15080. PMCID: PMC8525323 |
55. Isaeva E, Bohovyk R, Fedoriuk M, Shalygin A, Klemens CA, Zietara A, Levchenko V, Denton JS, Staruschenko A, Palygin O. Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (K<sub>ir</sub> 4.1/K<sub>ir</sub> 5.1) in the cortical collecting duct. Br J Pharmacol. 2022 Jun;179(12):2953-2968. PMCID: PMC9106811 |
56. Garvin J, Semenikhina M, Liu Q, Rarick K, Isaeva E, Levchenko V, Staruschenko A, Palygin O, Harder D, Cohen S. Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R571-R580. PMCID: PMC9109795 |
57. McClenahan SJ, Kent CN, Kharade SV, Isaeva E, Williams JC, Han C, Terker A, Gresham R 3rd, Lazarenko RM, Days EL, Romaine IM, Bauer JA, Boutaud O, Sulikowski GA, Harris R, Weaver CD, Staruschenko A, Lindsley CW, Denton JS. VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels. Mol Pharmacol. 2022 May;101(5):357-370. PMCID: PMC9092466 |
58. Nikolaienko O, Isaeva EV. Adult resocialization restores sociability, reduced by adolescent social isolation in rats Fiziologichnyi Zhurnal. 2022;68(2):9-13. |
59. Semenikhina M, Bogovik R, Fedoryuk M, Lunko , Savotchenko A, Isaeva E. PHARMACOLOGICAL BLOCKADE OF PROTEASE-ACTIVATED RECEPTORS 1 NORMALIZES BEHAVIORAL HYPEREXCITABILITY OF RATS IN THE LATENT STAGE OF THE EXPERIMENTAL MODEL OF TEMPORAL LOBE EPILEPSY Fiziologichnyi Zhurnal. 2019;65(3):7-11. |
60. Savotchenko AV, Semenikhina MO, Krasnianchuk IV, Bogovyk RI, Honcharova AE, Isaeva EV. BEHAVIORAL CONSEQUENCES OF ENTEROBIASIS IN RATS Fiziologichnyi Zhurnal. 2019;65(1):20-25. |
61. Xu B, Nikolaienko O, Levchenko V, Choubey AS, Isaeva E, Staruschenko A, Palygin O. Modulation of P2X<sub>4</sub> receptor activity by ivermectin and 5-BDBD has no effect on the development of ARPKD in PCK rats. Physiol Rep. 2022 Nov;10(21):e15510. PMCID: PMC9647406 |
62. Waltz TB, Chao D, Prodoehl EK, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL. Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry disease. bioRxiv. 2023 May 28. PMCID: PMC10245981 |
63. Nagree MS, Rybova J, Kleynerman A, Ahrenhoerster CJ, Saville JT, Xu T, Bachochin M, McKillop WM, Lawlor MW, Pshezhetsky AV, Isaeva O, Budde MD, Fuller M, Medin JA. Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency. Commun Biol. 2023 May 25;6(1):560. PMCID: PMC10212955 |
64. Chulkov EG, Isaeva E, Stucky CL, Marchant JS. Use the force, fluke: Ligand-independent gating of Schistosoma mansoni ion channel TRPM<sub>PZQ</sub>. Int J Parasitol. 2023 Jul;53(8):427-434. PMCID: PMC10258140 |
65. Polat OK, Isaeva E, Sudhini YR, Knott B, Zhu K, Noben M, Suresh Kumar V, Endlich N, Mangos S, Reddy TV, Samelko B, Wei C, Altintas MM, Dryer SE, Sever S, Staruschenko A, Reiser J. The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5. Kidney Int. 2023 Jun;103(6):1056-1062. PMCID: PMC10200725 |
66. Mikesell AR, Isaeva O, Moehring F, Sadler KE, Menzel AD, Stucky CL. Keratinocyte PIEZO1 modulates cutaneous mechanosensation. Elife. 2022 Sep 02;11. PMCID: PMC9512397 |
67. Nikolaienko O, Klymenko M, Isaeva E. Consequences of adolescent social isolation on behavior and synaptic plasticity in the dorsal and ventral hippocampus in male Wistar rats. Neurol Res. 2023 Dec;45(12):1152-1160. |
68. Savotchenko AV, Isaeva EV, Isaev DS. Pharmacological blockade of neuraminidase activity does not affect paired-pulse plasticity in hippocampal CA3-to-CA1 network Biopolymers and Cell. 2023;39(2):146-151. |
69. Savotchenko AV, Isaeva EV, Isaev DS. EFFECT OF NEURAMINIDASE INHIBITION ON VARIATION OF FIELD EXTRACELLULAR POTENTIALS IN RAT HIPPOCAMPAL NETWORK Fiziologichnyi Zhurnal. 2023;69(4):40-44. |
70. Bohovyk R, Khedr S, Levchenko V, Stefanenko M, Semenikhina M, Kravtsova O, Isaeva E, Geurts AM, Klemens CA, Palygin O, Staruschenko A. Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy. Diabetes. 2023 Dec 01;72(12):1795-1808. PMCID: PMC10658073 |
71. Waltz TB, Chao D, Prodoehl EK, Enders JD, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL. Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity. JCI Insight. 2024 Mar 07;9(8). PMCID: PMC11141882 |
72. Allison RL, Welby E, Ehlers V, Burand A, Isaeva O, Nieves Torres D, Highland J, Brandow AM, Stucky CL, Ebert AD. Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient plasma. Blood. 2024 May 16;143(20):2037-2052. PMCID: PMC11143522 |
73. Yang C, Isaeva E, Shimada S, Kurth T, Stumpf M, Zheleznova NN, Staruschenko A, Dash RK, Cowley AW Jr. Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity. Am J Physiol Renal Physiol. 2024 Sep 01;327(3):F435-F449. PMCID: PMC11460535 |
74. Mikesell AR, Isaeva E, Schulte ML, Menzel AD, Sriram A, Prahl MM, Shin SM, Sadler KE, Yu H, Stucky CL. Keratinocyte Piezo1 drives paclitaxel-induced mechanical hypersensitivity. bioRxiv. 2023 Dec 13. PMCID: PMC10760029 |
75. Mikesell AR, Isaeva E, Schulte ML, Menzel AD, Sriram A, Prahl MM, Shin SM, Sadler KE, Yu H, Stucky CL. Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity. Sci Transl Med. 2024 Dec 11;16(777):eadn5629. |
