Medical College of Wisconsin
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Scott Terhune PhD
Department of Microbiology and Immunology

Basic Science Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

Refereed Journal Publications/Original Papers
1. Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S. MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection. Mol Immunol. 2021 09;137:94-104.
2. Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S. Implications of a 'Third Signal' in NK Cells. Cells. 2021 07 31;10(8). PMCID: PMC8393955
3. Jung Y, Kraikivski P, Shafiekhani S, Terhune SS, Dash RK. Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis. NPJ Syst Biol Appl. 2021 12 09;7(1):46. PMCID: PMC8660825
4. Dean HJ, Terhune SS, Shieh MT, Susmarski N, Spear PG. Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity. Virology. 1994 Feb 15;199(1):67-80.
5. Terhune SS, Coleman KT, Sekulovich R, Burke RL, Spear PG. Limited variability of glycoprotein gene sequences and neutralizing targets in herpes simplex virus type 2 isolates and stability on passage in cell culture. J Infect Dis. 1998 Jul;178(1):8-15.
6. Thomas JT, Oh ST, Terhune SS, Laimins LA. Cellular changes induced by low-risk human papillomavirus type 11 in keratinocytes that stably maintain viral episomes. J Virol. 2001 Aug;75(16):7564-71. PMCID: PMC114991
7. Dean HJ, Warner MS, Terhune SS, Johnson RM, Spear PG. Viral determinants of the variable sensitivity of herpes simplex virus strains to gD-mediated interference. J Virol. 1995 Aug;69(8):5171-6. PMCID: PMC189341
8. Terhune SS, Milcarek C, Laimins LA. Regulation of human papillomavirus type 31 polyadenylation during the differentiation-dependent life cycle. J Virol. 1999 Sep;73(9):7185-92. PMCID: PMC104242
9. Terhune SS, Hubert WG, Thomas JT, Laimins LA. Early polyadenylation signals of human papillomavirus type 31 negatively regulate capsid gene expression. J Virol. 2001 Sep;75(17):8147-57. PMCID: PMC115059
10. Goodrum F, Jordan CT, Terhune SS, High K, Shenk T. Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations. Blood. 2004 Aug 01;104(3):687-95.
11. Terhune SS, Schr??er J, Shenk T. RNAs are packaged into human cytomegalovirus virions in proportion to their intracellular concentration. J Virol. 2004 Oct;78(19):10390-8. PMCID: PMC516422
12. Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D. Human cytomegalovirus UL38 protein blocks apoptosis. J Virol. 2007 Apr;81(7):3109-23. PMCID: PMC1866066
13. Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T. Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe. 2008 Apr 17;3(4):253-62. PMCID: PMC2759192
14. Mitchell DP, Savaryn JP, Moorman NJ, Shenk T, Terhune SS. Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs. J Virol. 2009 Oct;83(19):10187-97. PMCID: PMC2748044
15. Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T. Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol. 2010 Aug;84(15):7803-14. PMCID: PMC2897612
16. Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T. Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. PLoS Pathog. 2010 Jun 24;6(6):e1000965. PMCID: PMC2891856
17. Reitsma JM, Savaryn JP, Faust K, Sato H, Halligan BD, Terhune SS. Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. Cell Host Microbe. 2011 Feb 17;9(2):103-14.
18. White MJ, Savaryn JP, Bretl DJ, He H, Penoske RM, Terhune SS, Zahrt TC. The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. PLoS One. 2011 Mar 22;6(3):e18175. PMCID: PMC3062566
19. Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW. Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU. Mol Microbiol. 2011 Dec;82(6):1454-67. PMCID: PMC3237844
20. Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D. Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS Pathog. 2012;8(7):e1002789. PMCID: PMC3390409
21. Lam V, Bigley T, Terhune SS, Wakatsuki T. A method for quantifying mechanical properties of tissue following viral infection. PLoS One. 2012;7(8):e42197. PMCID: PMC3411685
22. Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS. Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection. J Virol. 2013 Mar;87(5):2463-74. PMCID: PMC3571358
23. Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL. A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. J Virol. 2013 Jul;87(13):7314-25. PMCID: PMC3700300
24. Bigley TM, Reitsma JM, Mirza SP, Terhune SS. Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. J Virol. 2013 Jul;87(13):7393-408. PMCID: PMC3700266
25. Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C. Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus. J Virol. 2013 Oct;87(19):10763-76. PMCID: PMC3807375
26. Rowles DL, Terhune SS, Cristea IM. Discovery of host-viral protein complexes during infection. Methods Mol Biol. 2013;1064:43-70. PMCID: PMC4162421
27. Reitsma JM, Terhune SS. Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection. Antiviral Res. 2013 Nov;100(2):321-7. PMCID: PMC3845884
28. Bretl DJ, Bigley TM, Terhune SS, Zahrt TC. The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system. J Bacteriol. 2014 Jan;196(2):391-406. PMCID: PMC3911260
29. Carter DM, Westdorp K, Noon KR, Terhune SS. Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection. Proteomics. 2015 Jun;15(12):1995-2005. PMCID: PMC4556115
30. Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL. Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. J Proteomics. 2016 Feb 16;134:76-84. PMCID: PMC4633404
31. Bigley TM, Reitsma JM, Terhune SS. Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection. J Virol. 2015 Oct;89(20):10230-46. PMCID: PMC4580190
32. Bigley TM, McGivern JV, Ebert AD, Terhune SS. Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation. Antiviral Res. 2016 May;129:67-73. PMCID: PMC4957402
33. Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F. Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. PLoS Pathog. 2016 05;12(5):e1005655. PMCID: PMC4878804
34. Greseth MD, Carter DC, Terhune SS, Traktman P. Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation. Mol Cell Proteomics. 2017 04;16(4 suppl 1):S124-S143. PMCID: PMC5393388
35. Westdorp KN, Sand A, Moorman NJ, Terhune SS. Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection. J Virol. 2017 09 15;91(18). PMCID: PMC5571270
36. Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL. SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. Oncogene. 2017 12 14;36(50):6873-6883. PMCID: PMC5730474
37. Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL. Correction for Mounce et al., "A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages". J Virol. 2018 01 01;92(1). PMCID: PMC5730793
38. Westdorp KN, Terhune SS. Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication. Antiviral Res. 2018 05;153:33-38. PMCID: PMC6015744
39. Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC. Association of Mycobacterium Proteins with Lipid Droplets. J Bacteriol. 2018 08 15;200(16). PMCID: PMC6060360
40. Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M. Isomer-specific effect of microRNA miR-29b on nuclear morphology. J Biol Chem. 2018 09 07;293(36):14080-14088. PMCID: PMC6130969
41. Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F. Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency. J Virol. 2018 10 15;92(20). PMCID: PMC6158428
42. Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M. Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency. mBio. 2018 09 11;9(5). PMCID: PMC6134100
43. Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD. Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids. J Virol. 2019 09 01;93(17). PMCID: PMC6694809
44. Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F. Erratum for Rak et al., "Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency". J Virol. 2020 03 17;94(7). PMCID: PMC7081901
45. Terhune SS, Jung Y, Cataldo KM, Dash RK. Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle. PLoS Comput Biol. 2020 04;16(4):e1007733. PMCID: PMC7162553
46. Mokry RL, Schumacher ML, Hogg N, Terhune SS. Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection mBio. November-December 2020;11(6):1-25.
47. Maranto C, Udhane V, Jia J, Verma R, M??ller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT. Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. Cancers (Basel). 2020 Nov 18;12(11). PMCID: PMC7724566
48. Mokry RL, Schumacher ML, Hogg N, Terhune SS. Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection. mBio. 2020 12 15;11(6). PMCID: PMC7773989
49. O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD. Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus iScience. 15 April 2022;25(4).
50. Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S. Method to Study Adaptive NK Cells Following MCMV Infections. Methods Mol Biol. 2022;2463:195-204.
51. Albright ER, Morrison K, Ranganathan P, Carter DM, Nishikiori M, Lee JH, Slayton MD, Ahlquist P, Terhune SS, Kalejta RF. Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function. Proc Natl Acad Sci U S A. 2022 04 05;119(14):e2122174119. PMCID: PMC9169081
52. O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD. Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus. iScience. 2022 Apr 15;25(4):104098. PMCID: PMC8980761