CURRICULUM VITAE
Yi-Guang Chen PhD
Yi-Guang Chen PhD
Professor
Department of Pediatrics
Division of Endocrinology
Department of Pediatrics
Division of Endocrinology
OFFICE ADDRESS: |
Translational and Biomedical Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
- 1993 BS - Medical Technology, National Taiwan University, Taipei, Taiwan |
- 2002 PhD - Pathology and Laboratory Medicine, University of Rochester, Rochester, NY |
FACULTY APPOINTMENTS: |
02/2007 - 08/2010 Research Scientist, Jackson Laboratory, Bar Harbor, ME |
09/2010 - 06/2015 Assistant Professor, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI |
01/2011 - 06/2015 Assistant Professor, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI |
07/2015 - 06/2021 Associate Professor, Department of Pediatrics, Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI |
11/2016 - Present Adjunct Faculty, Jackson Laboratory, Bar Harbor, ME |
07/2021 - Present Professor, Department of Pediatrics, Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, Milwaukee, WI |
AWARDS AND HONORS: |
2003 - 2005 Postdoctoral Fellowship, Juvenile Diabetes Research Foundation |
07/2007 - 2010 Pathway to Independence Award (K99), National Institute of Health |
2007 - 2010 Pathway to Independence Award (R00), National Institute of Health |
- 11/2022 Outstanding Graduate School Educator, Medical College of Wisconsin |
- 10/2005 Travel Award , Immunology of Diabetes Society 8th meeting |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2004 - Present American Diabetes Association (Member) |
2007 - Present American Association of Immunologists (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2019 - 2021 Scientific Reports |
2021 - 2022 Guest Editor, Frontiers in Immunology |
Journal Review |
PNAS |
Diabetes |
Diabetologia |
Clinical and Experimental Immunology |
Journal of Autoimmunity |
Immunobiology |
Immunology Letters |
DNA Sequence |
European Journal of Immunology |
Cytokine |
Journal of Leukocyte Biology |
Cell Reports |
Journal of Immunology |
Molecular Therapy |
Nature Immunology |
Mammalian Genome |
PLOS ONE |
PLOS Genetics |
Autoimmunity |
Genes and Immunity |
Scientific Reports |
Frontiers in Immunology |
Immunity |
Journal of Experimental Medicine |
Nature Medicine |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
Mechanistic basis of NKT cell mediated diabetes protection in NOD mice, The 63rd American Diabetes Association scientific sessions, New Orleans, LA, 06/13/2003 - 06/17/2003 |
Accelerated type 1 diabetes in CD38-deficient NOD mice through a further loss of disease protective NKT cells and mature dendritic cells, The 65th American Diabetes Association scientific sessions, San Diego, CA, 06/10/2005 - 06/14/2005 |
Accelerated type 1 diabetes in CD38-deficient NOD mice: a further impairment of the NKT-DC axis, Trudeau Institute, Trudeau Institute, NY, 2005 |
CD38 is required for peripheral survival of tolerogenic CD4+ iNKT cells in NOD mice, Abstract of the American Association of Immunologist annual meeting, Boston, MA, 2006 |
Gene expression and sub-congenic analyses of the Idd9/11 locus that regulates the diabetogenic activity of CD4 T-cells in NOD mice, The American Association of Immunologist annual meeting, Boston, MA, 05/04/2012 - 05/08/2012 |
Zinc-finger nuclease mediated mutagenesis reveals a role of CD137 in type 1 diabetes, Pathology Grand Rounds, University of Florida, Gainesville, FL, 2015 |
Zinc-finger nuclease mediated mutagenesis reveals a role of CD137 in type 1 diabetes, Program in Immunology Seminar Series, University of Alabama at Birmingham, Birmingham, AL, 2015 |
Zinc Finger Nuclease-mediated Mutagenesis Reveals a Critical Role of Ubash3a in Type 1 Diabetes, The 76th American Diabetes Association scientific sessions, New Orleans, LA, 06/10/2016 - 06/14/2016 |
Dissecting the genetic control of type 1 diabetes in NOD mice, University of Illinois College of Medicine at Rockford, Rockford, IL, 2016 |
Genetic control of immune dysregulation in the NOD mouse model of type 1 diabetes, Interdisciplinary Graduate Program in Immunology, University of Iowa, 2017 |
Interleukin-27 plays a pathogenic role in type 1 diabetes, University of Illinois College of Medicine at Rockford, Rockford, IL, 2017 |
The multifaceted role of CD137 in autoimmune type 1 diabetes, University of Illinois College of Medicine at Rockford, Rockford, IL, 2021 |
Local |
NKT cells mediate diabetes protection in NOD mice through their downstream effects on dendritic cells, Immunology/Hematology Interest Group, The Jackson Laboratory, Bar Harbor, ME, 2005 |
Genetic control of diabetogenic T cell development in NOD mice, Immunology/Hematology Interest Group, The Jackson Laboratory, Bar Harbor, ME, 2007 |
Decoding the NOD code for type 1 diabetes susceptibility genes, Immunology/Hematology Interest Group, The Jackson Laboratory, Bar Harbor, ME, 2008 |
Genetic control of diabetogenic CD4 T cells in NOD mice, Immunology/Hematology Interest Group, The Jackson Laboratory, Bar Harbor, ME, 2009 |
Dissecting the genetic control of type 1 diabetes in NOD mice, Human and Molecular Genetics Center Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 2010 |
Further testing the NKT cell hypothesis in type 1 diabetes, Immunology/Hematology Interest Group, The Jackson Laboratory, Bar Harbor, ME (2010), 2010 |
Dissecting the genetic control of type 1 diabetes in NOD mice, Genetics Interest Group, The Jackson Laboratory, Bar Harbor, ME, 2010 |
Further testing the NKT cell hypothesis in type 1 diabetes., Immunolunch. Blood Research Institute, Milwaukee, WI, 2011 |
Dissecting the genetic control of type 1 diabetes in NOD mice, 3rd Annual Committee on Immunology Conference, Blood Research Institute, Milwaukee, WI, 2011 |
Genetics of type 1 diabetes in a mouse model, CRI Research Conference, Medical College of Wisconsin, Milwaukee, WI, 2012 |
Dissecting the genetic control of type 1 diabetes in NOD mice, Human and Molecular Genetics Center Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 2012 |
Dissecting the genetic control of type 1 diabetes in NOD mice, Human and Molecular Genetics Center Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 2013 |
Dissecting the genetic control of type 1 diabetes in NOD mice, 5th Annual Committee on Immunology Conference,, Blood Research Institute, Milwaukee, WI, 2013 |
Genetic control of type 1 diabetes in NOD mice, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 2014 |
An update on the NOD mouse knockout project, Immunolunch, Blood Research Institute, Milwaukee, WI, 2014 |
A NOD to animal models of type 1 diabetes, Biomedical Resource Center staff meeting, Medical College of Wisconsin, Milwaukee, WI, 2014 |
A NOD to animal models of type 1 diabetes, Redox Biology Program, Medical College of Wisconsin, Milwaukee, WI, 2014 |
A NOD to animal models of type 1 diabetes, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 2015 |
Genetic control of type 1 diabetes: learning from the NOD mouse, Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, 2017 |
Genetic control of type 1 diabetes: learning from the NOD mouse, 11th Annual Immunology Symposium, Blood Research Institute, Milwaukee, WI, 2017 |
Testing human type 1 diabetes genes in the NOD mouse model, 10th Annual Immunology Scientific Retreat, Blood Research Institute, Milwaukee, WI, 2018 |
Shaping diabetogenic T cells by IL-27 in type 1 diabetes, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 2019 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Chen, Y.-G., M.A. Pierce, T.M. Holl, S.B. Wilson and D.V. Serreze, Mechanistic basis of NKT cell mediated diabetes protection in NOD mice, The Immunology of Diabetes Society 7th meeting, Cambridge, UK, 03/28/2004 - 03/31/2004 |
Chen, Y.-G, J. Chen, S.B. Wilson, E.H. Leiter, and D.V. Serreze, Accelerated type 1 diabetes in CD38-deficient NOD mice through a further loss of disease protective NKT cells and mature dendritic cells, The Immunology of Diabetes Society 8th meeting, Japan, 2005 |
National |
Chen, Y.-G., M.A. Pierce, T.M. Holl, S.B. Wilson, and D.V. Serreze, Mechanistic basis of NKT cell mediated diabetes protection in NOD mice, The 63rd American Diabetes Association scientific sessions, New Orleans, LA, 06/13/2003 - 06/17/2003 |
Chen, Y.-G., J. Chen, S.B. Wilson, E.H. Leiter, and D.V. Serreze, Accelerated type 1 diabetes in CD38-deficient NOD mice through a further loss of disease protective NKT cells and mature dendritic cells, The 65th American Diabetes Association scientific sessions, San Diego, CA, 06/10/2005 - 06/14/2005 |
Chen, Y.-G., S.B. Wilson, E.H. Leiter, and D.V. Serreze, CD38 is required for peripheral survival of tolerogenic CD4+ iNKT cells in NOD mice, Abstract of the American Association of Immunologist annual meeting, Boston, MA, 2006 |
Chen, Y.-G., F. Scheuplein, M.A. Osborne, H.D. Chapman, and D.V. Serreze, Idd9/11 regulates diabetogenic activity of CD4 T cells in NOD mice, The Immunology of Diabetes Society 9th meeting, Miami Beach, Florida, 11/14/2007 - 11/18/2007 |
Chen, Y.-G. and D.V. Serreze., Multiple genes within the Idd9.1 region regulate iNKT cells and type 1 diabetes in NOD mice, The FOCIS meeting, Boston, MA, 06/24/2010 - 06/27/2010 |
Chen, Y.-G. and D.V. Serreze, The Idd9/11 genetic locus regulates the diabetogenic activity of CD4 T-cells in non-obese diabetic (NOD) mice through an enhanced regulatory T-cell activity, The 71st American Diabetes Association scientific sessions, San Diego, CA., 06/24/2011 - 06/28/2011 |
Chen, Y.-G., S. Jia, M. Kaldunski, D. Serreze, and M. Hessner, Gene expression and sub-congenic analyses of the Idd9/11 locus that regulates the diabetogenic activity of CD4 T-cells in NOD mice, The American Association of Immunologist annual meeting, 2012 |
Chen, Y.-G., S. Jia, M. Kaldunski, D. Serreze, and M. Hessner, Gene expression and sub-congenic analyses of the Idd9/11 locus that regulates the diabetogenic activity of CD4 T-cells in NOD mice, IDS12 meeting, 2012 |
Tsaih, S.-W., S. Khaja, A.E. Ciecko, E. MacKinney, and Y.-G. Chen*, Genetic control of murine invariant natural killer T-cells maps to multiple type 1 diabetes regions, The 73rd American Diabetes Association scientific sessions, Chicago, IL, 06/21/2013 - 06/25/2013 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2011 Member of Committee on Defining HMGC, Human and Molecular Genetics Center (HMGC) |
2012 Member, Expert Panel for Endocrinology-Reproduction M2 Discovery Curriculum, Medical College of Wisconsin |
2013 - 2022 Institutional Animal Care and Use Committee (IACUC) |
2014 Reviewer for selecting a grant application to represent MCW to apply for the American Diabetes Association Pathway Awards |
2014 - Present Fellowship Program Evaluation Committee, Division of Endocrinology, Department of Pediatrics |
2014 Judge for Medical Student Research Day poster contest |
2015 Judge for Medical Student Research Day poster contest |
2016 - Present CRI Pilot Grant Review committee |
2016 Judge for Graduate Student Research Day poster contest |
2017 Immunology Faculty Recruitment Committee,, Dept. of Microbiology and Immunology |
MCW TEACHING ACTIVITIES: |
Graduate Student Education |
04/2012 - 04/2019 Classical and Molecular Genetics |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
06/2011 - 08/2011 Wei Gang Andrew Wang, summer student mentor Medical Student Research Fellowship awarded, Medical College of Wisconsin, Winner of Dr. Michael J. Dunn Poster Contest Award for Medical Student Research Day |
Graduate Students |
PhD Committees |
02/2011 - Present Angela Henschel, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
06/2015 - 08/2015 Michelle Lazar, Internship |
06/2018 - 08/2018 Janani Sundar, Internship |
06/2019 - 08/2019 Sabrina Huang, Internship |
Undergraduate Students |
06/2018 - 08/2018 Alisa Erck, College intern |
Medical Students |
07/2012 - 05/2013 Wei Gang Andrew Wang, Physician scientist pathway mentor |
06/2013 - 08/2013 Jonathan D. Bernard, Summer student mentor |
08/2013 - 05/2015 Jonathan D. Bernard, Physician scientist pathway mentor |
06/2014 - 08/2014 Bixuan Lin, Summer student mentor, Winner of Dr. Michael J. Dunn Poster Contest Award for Medical Student Research Day |
08/2014 - 05/2016 Bixuan Lin, Physician scientist pathway mentor |
06/2015 - 08/2015 Jane Lee, Summer student mentor, Winner of Dr. Michael J. Dunn Poster Contest Award for Medical Student Research Day |
08/2015 - 05/2016 Jane Lee, Physician scientist pathway mentor |
06/2016 - 08/2016 Katherine D. Umhoefer, Summer student mentor |
06/2017 - 08/2017 Matthew Gonzalez, Summer student mentor |
Graduate Students |
Students Advised |
01/2012 - 02/2012 Ashley Gehrand |
03/2012 - 04/2012 Matthew Forsberg |
08/2015 - 10/2015 Ashley Ciecko, Winner of 25th Annual Graduate School of Biomedical Sciences Research Poster Award |
01/2016 - 03/2016 Chay Teng Yeo |
03/2016 - 05/2016 Freidrich Seewald |
01/2019 - 02/2019 Weiyi Guo |
02/2019 - 04/2019 Kyle Stoltz |
01/06/2020 - 02/2020 Yiwei Kong |
Committees |
12/2012 Matthew Forsberg |
12/2013 Joo-Hyung Lee |
11/2016 Ashley Ciecko |
12/2019 Kayla Schwartz |
Postdoctoral Students |
01/2017 - 12/2019 Bardees Foda, Abstract winner for the 10th Annual Immunology Scientific retreat. Oct 18, 2018 |
10/2020 - 01/2022 Ashley Ciecko |
04/2021 - Present Tarun Pant |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Ou-Yang, P., B.-L. Chiang, L.-H. Hwang, Y.-G. Chen, P.-M. Yang, W.-K. Chi, P.-J. Chen, D.-S. Chen. Characterization of monoclonal antibodies against hepatitis C virus nonstructural protein 3: different antigenic determinants from human B cells. J. Med. Virol. 1999; 57: 345-350. |
2. Chien, T.-I., Y.-G. Chen, B.-L. Chiang. Preparation of Der p1 specific monoclonal antibodies and use in a two-site-ELISA to detect Der p1 allergen. J. Microbiol. Immunol. Infect. 2000; 33: 87-92. |
3. Chen, Y.-G., A. Mantalaris, P. Bourne, P. Keng, J.H.D. Wu. Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow. Biochem. Biophys. Res. Commun. 2000; 276: 724-728. |
4. Omasa, T., Y.-G. Chen, A. Mantalaris, J.H.D. Wu. A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP11/PLM/MAT8 family of transmembrane proteins. Biochim. Biophys. Acta. 2001; 1517: 307-310. |
5. Omasa, T., Y.-G. Chen, A. Mantalaris, Y.-C. Tsai, and J.H.D. Wu. Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor-2 alpha (eIF-2 alpha) kinase from bone marrow culture. DNA Sequence 2002; 13: 133-137. |
6. Chen, Y.-G., C.-M. Choisy-Rossi, T.M. Holl, H.D. Chapman, G.S. Besra, S.A. Porcelli, D.J. Shaffer, D. Roopenian, S. B. Wilson, and D.V. Serreze. Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. J. Immunol. 2005; 174: 1196-1204. |
7. Lee, C.-H., Y.-G. Chen, J. Chen, P.C. Reifsnyder, D.V. Serreze, M. Clare-Salzler, M. Rodriguez, C. Wasserfall, M.A. Atkinson, and E.H. Leiter. Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression. II. immunologic analysis. Diabetes 2006; 55: 171-178. |
8. Chen J., Y.-G. Chen, P.C. Reifsnyder, W.H. Schott, C.-H. Lee, F. Scheuplein, F. Haag, F. Koch-Nolte, D.V. Serreze, and E.H. Leiter. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ART2-dependent fashion. J. Immunol. 2006; 176: 4590-94599. |
9. Chen, Y.-G., J. Chen, M.A. Osborne, H.D. Chapman, G.S. Besra, S.A. Porcelli, E.H. Leiter, S.B. Wilson, and D.V. Serreze. CD38 Is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J. Immunol. 2006; 177: 2939-2947. |
10. Serreze, D.V., M.A. Osborne, Y.-G. Chen, H.D. Chapman, T. Pearson, M.A. Brehm, D.L. Greiner. Partial versus full allogeneic hematopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. J. Immunol. 2006; 177: 6675-6684. |
11. Chen, Y.-G., P.A. Silveira, M.A. Osborne, H.D. Chapman, D.V. Serreze. Cellular expression requirement for inhibition of type 1 diabetes by a dominantly protective MHC haplotype. Diabetes 2007; 56: 424-430. |
12. Chen, Y.-G., J.P. Driver, P.A. Silveria, D.V. Serreze, Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. Immunogenetics 2007; 59:705-712. |
13. Mukhopadhaya A., T. Hanafusa, I. Jarchum , Y.-G. Chen, Y. Iwai , D.V. Serreze, R.M. Steinman, K.V. Tarbell T.P. DiLorenzo . Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. Proc Natl Acad Sci U S A. 2008; 105:6374-9. |
14. Chen, Y.-G., F. Scheuplein, M.A. Osborne, S.-W. Tsaih, H.D. Chapman, D.V. Serreze. The Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in non-obese diabetic (NOD) mice. Diabetes 2008; 57:3273-3280. |
15. Scheuplein, F., B. Rissiek, J.P. Driver, Y.-G. Chen, F. Koch-Nolte, and D.V. Serreze, A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. J. Autoimmunity 2010; 34:145-54. |
16. Driver, J.P., F. Scheuplein, Y.-G. Chen, A.E. Grier, S.B. Wilson, and D.V. Serreze, iNKT-cell control of Type-1 Diabetes:a Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette. Diabetes 2010; 59:423-32. |
17. Driver, J.P., Y.-G. Chen, W. Zhang, S. Asrat, and D. V. Serreze, Unmasking genes in a type 1 diabetes resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes 2011; 60:1354-9. |
18. Chen, Y.-G., F. Scheuplein, J.P. Driver, A.A. Hewes, P.C. Reifsnyder, E.H. Leiter, and D.V. Serreze, Testing the Role of P2X7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice. J. Immunol. 2011; 186:4278-84. |
19. Chen YG, Tsaih SW, Serreze DV. Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. Genes Immun. 2012 Feb;13(2):164-74. PMCID: PMC3291802 |
20. Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA. Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. J Immunol. 2012 Aug 01;189(3):1406-17. PMCID: PMC3401322 |
21. Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia. 2012 Nov;55(11):3010-20. |
22. Bogdani M, Henschel AM, Kansra S, Fuller JM, Geoffrey R, Jia S, Kaldunski ML, Pavletich S, Prosser S, Chen YG, Lernmark A, Hessner MJ. Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. J Endocrinol. 2013 Feb;216(2):111-23. PMCID: PMC4077722 |
23. Tsaih SW, Khaja S, Ciecko AE, MacKinney E, Chen YG. Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions. Genes Immun. 2013 Sep;14(6):380-6. PMCID: PMC3766462 |
24. Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ. Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. Genes Immun. 2013 Sep;14(6):387-400. PMCID: PMC4027975 |
25. Driver JP, Chen YG, Mathews CE. Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes. Rev Diabet Stud. 2012;9(4):169-87. PMCID: PMC3740689 |
26. Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM. Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 2014 Jan;63(1):68-74. PMCID: PMC3868049 |
27. Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ. Molecular signatures differentiate immune states in type 1 diabetic families. Diabetes. 2014 Nov;63(11):3960-73. PMCID: PMC4207392 |
28. Tsaih SW, Presa M, Khaja S, Ciecko AE, Serreze DV, Chen YG. A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells. Genes Immun. 2015;16(3):221-30. PMCID: PMC4409484 |
29. Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H. Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. Genetics. 2015 Jun;200(2):423-30. PMCID: PMC4492369 |
30. Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. J Immunol. 2015 Oct 01;195(7):3011-9. PMCID: PMC4575869 |
31. Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ, Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T, AIDA Study Group, Hessner MJ. Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset. Eur J Immunol. 2016 Apr;46(4):1030-46. PMCID: PMC4828314 |
32. Cepero-Donates Y, Lacraz G, Ghobadi F, Rakotoarivelo V, Orkhis S, Mayhue M, Chen YG, Rola-Pleszczynski M, Menendez A, Ilangumaran S, Ramanathan S. Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease. Cytokine. 2016 Jun;82:102-11. |
33. Tsao CC, Tsao PN, Chen YG, Chuang YH. Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. PLoS One. 2016;11(1):e0147710. PMCID: PMC4727802 |
34. Cabrera SM, Chen YG, Hagopian WA, Hessner MJ. Blood-based signatures in type 1 diabetes. Diabetologia. 2016 Mar;59(3):414-25. PMCID: PMC4744128 |
35. Cepero-Donates Y, Rakotoarivelo V, Mayhue M, Ma A, Chen YG, Ramanathan S. Homeostasis of IL-15 dependent lymphocyte subsets in the liver. Cytokine. 2016 Jun;82:95-101. PMCID: PMC5293139 |
36. Lin B, Ciecko AE, MacKinney E, Serreze DV, Chen YG. Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. Immunogenetics. 2017 Mar;69(3):193-198. PMCID: PMC5335865 |
37. Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, Leeth CM, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV. Interferon-γ Limits Diabetogenic CD8<sup>+</sup> T-Cell Effector Responses in Type 1 Diabetes. Diabetes. 2017 Mar;66(3):710-721. PMCID: PMC5319715 |
38. Forsberg MH, Ciecko AE, Bednar KJ, Itoh A, Kachapati K, Ridgway WM, Chen YG. CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice. J Immunol. 2017 May 15;198(10):3857-3868. PMCID: PMC5426805 |
39. Henschel AM, Cabrera SM, Kaldunski ML, Jia S, Geoffrey R, Roethle MF, Lam V, Chen YG, Wang X, Salzman NH, Hessner MJ. Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility. PLoS One. 2018;13(1):e0190351. PMCID: PMC5749787 |
40. Racine JJ, Stewart I, Ratiu J, Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, Roopenian D, Schloss J, DiLorenzo TP, Serreze DV. Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes. 2018 May;67(5):923-935. PMCID: PMC5909999 |
41. Chen YG, Mathews CE, Driver JP. The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future. Front Endocrinol (Lausanne). 2018;9:51. PMCID: PMC5829040 |
42. Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV. A Hypermorphic <i>Nfkbid</i> Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8<sup>+</sup> T Cells in NOD Mice. J Immunol. 2018 Oct 01;201(7):1907-1917. PMCID: PMC6143397 |
43. Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ, Type 1 Diabetes TrialNet CTLA4-Ig (Abatacept) Study Group, Chen YG, Hessner MJ. Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes. Diabetologia. 2018 Nov;61(11):2356-2370. PMCID: PMC6182660 |
44. Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c<sup>+</sup> Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Front Immunol. 2019;10:99. PMCID: PMC6365440 |
45. Forsberg MH, Foda B, Serreze DV, Chen YG. Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus. Sci Rep. 2019 Mar 13;9(1):4316. PMCID: PMC6416332 |
46. Chen XL, Bobbala D, Rodriguez GM, Mayhue M, Chen YG, Ilangumaran S, Ramanathan S. Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells. Clin Exp Immunol. 2013 Aug;173(2):184-94. PMCID: PMC3722919 |
47. Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S. Erratum: Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse (Diabetologia DOI: 10.1007/s00125-012-2675- 1) Diabetologia. December 2012;55(12):3401. |
48. Gioia L, Holt M, Costanzo A, Sharma S, Abe B, Kain L, Nakayama M, Wan X, Su A, Mathews C, Chen YG, Unanue E, Teyton L. Position β57 of I-A<sup>g7</sup> controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset. Sci Immunol. 2019 Aug 30;4(38). PMCID: PMC6816460 |
49. Itoh A, Ortiz L, Kachapati K, Wu Y, Adams D, Bednar K, Mukherjee S, Chougnet C, Mittler RS, Chen YG, Dolan L, Ridgway WM. Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy Frontiers in Immunology. 7 November 2019;10. |
50. Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation Cell Reports. 2019. |
51. Itoh A, Ortiz L, Kachapati K, Wu Y, Adams D, Bednar K, Mukherjee S, Chougnet C, Mittler RS, Chen YG, Dolan L, Ridgway WM. Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy. Front Immunol. 2019;10:2566. PMCID: PMC6853870 |
52. Lee H, Lee YS, Harenda Q, Pietrzak S, Oktay HZ, Schreiber S, Liao Y, Sonthalia S, Ciecko AE, Chen YG, Keles S, Sridharan R, Engin F. Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes. Cell Metab. 2020 Apr 07;31(4):822-836.e5. PMCID: PMC7346095 |
53. Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG. The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137<sup>+</sup> FOXP3<sup>+</sup> Regulatory CD4 T Cells. J Immunol. 2020 Jun 01;204(11):2887-2899. PMCID: PMC7296588 |
54. Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S. Erratum: Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse (Diabetologia DOI: 10.1007/s00125-012-2675- 1) Diabetologia. December 2012;55(12):3401. |
55. Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM. UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Sci Rep. 2020 Jul 21;10(1):12019. PMCID: PMC7374577 |
56. Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation Frontiers in Immunology. 4 September 2020;11. |
57. Khatun A, Kasmani MY, Zander R, Schauder DM, Snook JP, Shen J, Wu X, Burns R, Chen YG, Lin CW, Williams MA, Cui W. Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire. J Exp Med. 2021 Mar 01;218(3). PMCID: PMC7676493 |
58. Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020;11:2180. PMCID: PMC7500101 |
59. Debreceni IL, Chimenti MS, Serreze DV, Geurts AM, Chen YG, Lieberman SM. Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice. Int J Mol Sci. 2020 Dec 13;21(24). PMCID: PMC7764018 |
60. Allred MG, Chimenti MS, Ciecko AE, Chen YG, Lieberman SM. Characterization of type i interferon‐associated chemokines and cytokines in lacrimal glands of nonobese diabetic mice International Journal of Molecular Sciences. 1 April 2021;22(7). |
61. Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Erratum: Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation (Cell Reports (2019) 29(10) (3073–3086.e5), (S2211124719314810), (10.1016/j.celrep.2019.11.010)) Cell Reports. 2 February 2021;34(5). |
62. Allred MG, Chimenti MS, Ciecko AE, Chen YG, Lieberman SM. Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice. Int J Mol Sci. 2021 Apr 05;22(7). PMCID: PMC8038628 |
63. Ciecko AE, Schauder DM, Foda B, Petrova G, Kasmani MY, Burns R, Lin CW, Drobyski WR, Cui W, Chen YG. Self-Renewing Islet TCF1<sup>+</sup> CD8 T Cells Undergo IL-27-Controlled Differentiation to Become TCF1<sup>-</sup> Terminal Effectors during the Progression of Type 1 Diabetes. J Immunol. 2021 Oct 15;207(8):1990-2004. PMCID: PMC8492517 |
64. Cabrera SM, Coren AT, Pant T, Ciecko AE, Jia S, Roethle MF, Simpson PM, Atkinson SN, Salzman NH, Chen YG, Hessner MJ. Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study. Sci Rep. 2022 Feb 28;12(1):3306. PMCID: PMC8885673 |
65. Kasmani MY, Ciecko AE, Brown AK, Petrova G, Gorski J, Chen YG, Cui W. Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage. Life Sci Alliance. 2022 Oct;5(10). PMCID: PMC9170949 |
66. Rojas M, Heuer LS, Zhang W, Chen YG, Ridgway WM. The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes. Front Immunol. 2022;13:918837. PMCID: PMC9353112 |
67. Sargin P, Roethle MF, Jia S, Pant T, Ciecko AE, Atkinson SN, Salzman NH, Teng RJ, Chen YG, Cabrera SM, Hessner MJ. <i>Lactiplantibacillus plantarum</i> 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats. Gut Microbes. 2022;14(1):2136467. PMCID: PMC9586621 |
68. Racine JJ, Morel L, Chen YG, Serreze DV. Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies. Front Immunol. 2022;13:1069232. PMCID: PMC9644883 |
69. Blum SI, Taylor JP, Barra JM, Burg AR, Shang Q, Qiu S, Shechter O, Hayes AR, Green TJ, Geurts AM, Chen YG, Tse HM. MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance. JCI Insight. 2023 Jan 24;8(2). PMCID: PMC9977297 |
70. Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG. Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. J Immunol. 2023 Apr 01;210(7):935-946. PMCID: PMC10483376 |
71. Khatun A, Wu X, Qi F, Gai K, Kharel A, Kudek MR, Fraser L, Ceicko A, Kasmani MY, Majnik A, Burns R, Chen YG, Salzman N, Taparowsky EJ, Fang D, Williams CB, Cui W. BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology. Adv Sci (Weinh). 2023 Oct;10(28):e2206692. PMCID: PMC10558681 |
72. Thirawatananond P, Brown ME, Sachs LK, Arnoletti JM, Yeh WI, Posgai AL, Shapiro MR, Chen YG, Brusko TM. Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability. Diabetes. 2023 Nov 01;72(11):1629-1640. PMCID: PMC10588280 |
73. Ye C, Clements SA, Gu W, Geurts AM, Mathews CE, Serreze DV, Chen YG, Driver JP. Deletion of Vβ3<sup>+</sup>CD4<sup>+</sup> T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8<sup>+</sup> T cells. Proc Natl Acad Sci U S A. 2023 Dec 05;120(49):e2312039120. PMCID: PMC10710095 |
74. Alvarez-Argote S, Paddock SJ, Flinn MA, Moreno CW, Knas MC, Almeida VA, Buday SL, Bakhshian Nik A, Patterson M, Chen YG, Lin CW, O'Meara CC. IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages. JCI Insight. 2024 Jan 23;9(2). PMCID: PMC10906228 |
75. Srivastava N, Hu H, Peterson OJ, Vomund AN, Stremska M, Zaman M, Giri S, Li T, Lichti CF, Zakharov PN, Zhang B, Abumrad NA, Chen YG, Ravichandran KS, Unanue ER, Wan X. CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8<sup>+</sup> T cells in diabetic autoimmunity. Immunity. 2024 Jul 09;57(7):1629-1647.e8. PMCID: PMC11236520 |
76. Pant T, Lin CW, Bedrat A, Jia S, Roethle MF, Truchan NA, Ciecko AE, Chen YG, Hessner MJ. Monocytes in type 1 diabetes families exhibit high cytolytic activity and subset abundances that correlate with clinical progression. Sci Adv. 2024 May 17;10(20):eadn2136. PMCID: PMC11100571 |
77. Debreceni IL, Barr JY, Upton EM, Chen YG, Lieberman SM. IL-27 promotes pathogenic T cells in a mouse model of Sjögren's disease. Clin Immunol. 2024 Jul;264:110260. PMCID: PMC11203157 |
Books, Chapters, and Reviews |
1. Serreze, D.V., Y.-G. Chen. Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. Trends Immunol. 2005; 26: 603-607. |
2. Driver, J.P., Serreze, D.V., Y.-G. Chen. Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol. 2011; 33:67-87. |
Abstracts |
1. Chen, Y.-G., M.A. Pierce, T.M. Holl, S.B. Wilson and D.V. Serreze. 2003. Mechanistic basis of NKT cell mediated diabetes protection in NOD mice. Abstract of the 63th American Diabetes Association scientific sessions. June 13-17, 2003. New Orlean, LA. |
2. Chen, Y.-G., M.A. Pierce, T.M. Holl, S.B. Wilson and D.V. Serreze. 2004. Mechanistic basis of NKT cell mediated diabetes protection in NOD mice. Abstract of the Immunology of Diabetes Society 7th meeting. p. 81. March 28-31, 2004. Cambridge, UK. |
3. Chen, Y.-G, J. Chen, S.B. Wilson, E.H. Leiter, D.V. Serreze. 2005. Accelerated type 1 diabetes in CD38-deficient NOD mice through a further loss of disease protective NKT cells and mature dendritic cells. Abstract of the Immunology of Diabetes Society 8th meeting. 2005, Japan. |
4. Chen, Y.-G., J. Chen, S.B. Wilson, E.H. Leiter, D.V. Serreze. 2005. Accelerated type 1 diabetes in CD38-deficient NOD mice through a further loss of disease protective NKT cells and mature dendritic cells. Abstract of the 65th American Diabetes Association scientific sessions. June 10-14, 2005. San Diego, CA. |
5. Chen, Y.-G., S.B. Wilson, E.H. Leiter, D.V. Serreze. 2006. CD38 is required for peripheral survival of tolerogenic CD4+ iNKT cells in NOD mice. Abstract of the American Association of Immunologist annual meeting. The Journal of Immunology, Supplement, 176: S138. |
6. Chen, Y.-G., F. Scheuplein, M.A. Osborne, H.D. Chapman, and D.V. Serreze. 2007. Idd9/11 regulates diabetogenic activity of CD4 T cells in NOD mice. Abstract of the Immunology of Diabetes Society 9th meeting. November 14-18, 2007. Miami Beach, Florida. Acta Diabetologica, Supplement 1, 44:S8. |
7. Driver, J.P., Y.-G. Chen, F. Scheuplein, D.V. Serreze. 2007. Strain dependent maturation of tolerogenic and immunogenic mouse dendritic cells induced by activated NKT cells. Acta Diabetologica, November 14-18, 2007. Miami Beach, Florida. Supplement 1, 44:S13. |
8. Driver, J.P., F. Scheuplein, Y.-G. Chen, D.V. Serreze. 2007. Activated NKT cells inhibit autoimmune Diabetes through tolerogenic maturation of dendritic cells. Abstract of the Keystone Symposia (Dendritic Cells). p. 132. |
9. Driver, J.P.,F. Scheuplein, Y.-G. Chen, D.V. Serreze. 2009. Strain dependent maturation of mouse dendritic cells by activated NKT cells: the implication for autoimmune diabetes. Abstract of the Keystone Symposia (Dendritic Cells). p. 216. |
10. Chen, Y.-G. and D.V. Serreze. 2010. Multiple genes within the Idd9.1 region regulate iNKT cells and type 1 diabetes in NOD mice. Abstract of the FOCIS meeting, June 24-27, 2010. Boston, MA. |
11. Ramanathan S., C. Leblanc, Y.-G. Chen and S. Ilangumaran. 2010. IL-21 is required for the pathogenicity of autoreactive CD8 T cells in a TCR transgenic model of autoimmune type 1 diabetes in the NOD mice. Abstract of the Annual Meeting of the French Society for Immunology. November 24 to 27, 2010. Marseilles, France. |
12. Chen, Y.-G. and D.V. Serreze. 2011. The Idd9/11 genetic locus regulates the diabetogenic activity of CD4 T-cells in non-obese diabetic (NOD) mice through an enhanced regulatory T-cell activity. Abstract of the 71th American Diabetes Association scientific sessions. June 24-28, 2011. San Diego, CA. |
Peer Reviewed Educational Products |
1. Chen, Y.-G., M.A. Pierce, T.M. Holl, S.B. Wilson and D.V. Serreze. Mechanistic basis of NKT cell mediated diabetes protection in NOD mice. The 63th American Diabetes Association scientific sessions. June 13-17, 2003. New Orlean, LA |
2. Chen, Y.-G., M.A. Pierce, T.M. Holl, S.B. Wilson and D.V. Serreze. Mechanistic basis of NKT cell mediated diabetes protection in NOD mice. The Immunology of Diabetes Society 7th meeting. March 28-31, 2004. Cambridge, UK |
3. Chen, Y.-G, J. Chen, S.B. Wilson, E.H. Leiter, D.V. Serreze. Accelerated type 1 diabetes in CD38-deficient NOD mice through a further loss of disease protective NKT cells and mature dendritic cells. The Immunology of Diabetes Society 8th meeting. 2005, Japan |
4. Chen, Y.-G., J. Chen, S.B. Wilson, E.H. Leiter, D.V. Serreze. Accelerated type 1 diabetes in CD38-deficient NOD mice through a further loss of disease protective NKT cells and mature dendritic cells. The 65th American Diabetes Association scientific sessions. June 10-14, 2005. San Diego, CA |
5. Chen, Y.-G., S.B. Wilson, E.H. Leiter, D.V. Serreze. CD38 is required for peripheral survival of tolerogenic CD4+ iNKT cells in NOD mice. Abstract of the American Association of Immunologist annual meeting. 2006, Boston, MA |
6. Chen, Y.-G., F. Scheuplein, M.A. Osborne, H.D. Chapman, and D.V. Serreze. Idd9/11 regulates diabetogenic activity of CD4 T cells in NOD mice. The Immunology of Diabetes Society 9th meeting. November 14-18, 2007. Miami Beach, Florida |
7. Chen, Y.-G. and D.V. Serreze. Multiple genes within the Idd9.1 region regulate iNKT cells and type 1 diabetes in NOD mice. The FOCIS meeting, June 24-27, 2010. Boston, MA |
8. Chen, Y.-G. and D.V. Serreze. 2011. The Idd9/11 genetic locus regulates the diabetogenic activity of CD4 T-cells in non-obese diabetic (NOD) mice through an enhanced regulatory T-cell activity. Abstract of the 71th American Diabetes Association scientific sessions. June 24-28, 2011. San Diego, CA. |
